The significance of the levels of IL-4, IL-31 and TLSP in patients with asthma and/or rhinitis

被引:37
作者
Chai, Ruonan [1 ]
Liu, Beixing [1 ]
Qi, Feifei [1 ]
机构
[1] China Med Univ, Dept Immunol, Shenyang 110010, Peoples R China
关键词
asthma; dust mite; mugwort; rhinitis; ALLERGIC AIRWAY INFLAMMATION; CYTOKINE PRODUCTION; CELLS; RESPONSES; DERMATITIS; DISEASE; MICE; TARC;
D O I
10.2217/imt-2016-0131
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Aim: To investigate the clinical significance of the levels of IL-4, IL-33 and thymic stromal lymphopoietin (TLSP) in patients with asthma and/or rhinitis, then do the simple verification in animals. Methods: Levels of IL-4 IL-31, IL-33 and TLSP were detected by ELISA and real-time PCR in 64 asthma patients (sIgE[+]: 32 cases, sIgE[-]: 32 cases), 64 rhinitis patients (sIgE[+]: 32 cases, sIgE[-]: 32 cases), 64 asthma complicated with allergic rhinitis patients (sIgE[+]: 32 cases, sIgE[-]: 32 cases) and 32 healthy controls. Then we detected the IL-4, IL-31, IL-33 and TLSP in the sensitized mice. Results: Results showed that levels of IL-4, IL-31, IL-33 and TSLP in asthma and rhinitis patients, and those complicated with allergic rhinitis, had significant differences compared with the control group (p < 0.05). It was found that the indicators of mugwort and dust mite allergic patients were significantly higher than that of other allergic patients (p < 0.05). We got the same tendency in in vivo experiments. Conclusion: IL-4, IL-31, IL-33 and TSLP may be involved in the pathogenesis of asthma and rhinitis; dust mite and mugwort allergy could increase them significantly.
引用
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页码:331 / 337
页数:7
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