Interplay between Ras-related and heterotrimeric GTP binding proteins: Lifestyles of the BIG and little

被引:31
作者
Bokoch, GM [1 ]
机构
[1] SCRIPPS RES INST, DEPT CELL BIOL IMM14, LA JOLLA, CA 92037 USA
关键词
G-protein; guanine nucleotide exchange factor; Pleckstrin homology; MAPK; PAK1;
D O I
10.1096/fasebj.10.11.8836042
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Directed interactions of heterotrimeric G-proteins coupled to receptors responding to extracellular signals and small Res-related GTPases that control a variety of intracellular processes are being elucidated by recent work, We explore two of the most well-characterized pathways that couple big G-proteins to their smaller relatives.
引用
收藏
页码:1290 / 1295
页数:6
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