Investigation of Copaifera genus as a new source of antimycobaterial agents

被引:7
作者
Alves, Jessica Aparecida [1 ]
Abrao, Fariza [1 ]
Moraes, Thais da Silva [1 ]
Damasceno, Jaqueline Lopes [1 ]
dos Santos Moraes, Marcos Fernando [2 ]
Sola Veneziani, Rodrigo Cassio [2 ]
Ambrosio, Sergio Ricardo [2 ]
Bastos, Jairo Kenupp [3 ]
Dantas Miranda, Mayker Lazaro [4 ]
Gomes Martins, Carlos Henrique [1 ,5 ]
机构
[1] Univ Franca, Res Lab Appl Microbiol, Franca, SP, Brazil
[2] Univ Franca, Nucleus Res Sci & Technol, Franca, SP, Brazil
[3] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Ribeirao Preto, SP, Brazil
[4] Fed Inst Educ Sci & Technol Triangulo Mineiro, Uberlandia, MG, Brazil
[5] Univ Fed Uberlandia, Lab Res Antimicrobial Trials LaPEA, Inst Biomed Sci ICBIM, Uberlandia, MG, Brazil
来源
FUTURE SCIENCE OA | 2020年 / 6卷 / 07期
基金
巴西圣保罗研究基金会;
关键词
antimicrobial activity; Copaifera spp; crude extracts; Mycobacterium tuberculosis; oleoresins; LANGSDORFFII OLEORESIN; DUCKEI OLEORESIN; NATURAL-PRODUCTS; ANTIBACTERIAL; TUBERCULOSIS; COPAIBA; DITERPENES; TERPENOIDS; SYNERGY; EXTRACT;
D O I
10.2144/fsoa-2020-0018
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Aim: This paper reports on the antimycobacterial activity of the oleoresins and extracts obtained from Copaifera spp. Materials & methods: The minimum inhibitory concentration (MIC) and fractional inhibitory concentration index techniques helped to evaluate the effect of these oleoresins and extracts against six strains of mycobacteria that cause tuberculosis. Results & conclusion: Among the assayed oleoresins and plant extracts, the Copaifera langsdorffii, Copaifera duckei, Copaifera reticulata and Copaifera trapezifolia oleoresins provided the lowest MIC values against some of the tested strains. The combination of Copaifera spp. samples with isoniazid did not evidence any synergistic action. Some Copaifera spp. oleoresins may represent a future source for the discovery of new antimycobacterial drugs due to their low MIC values. Lay abstract: The purpose of this paper was to evaluate the antimycobacterial activity of the oleoresins and extracts obtained from Copaifera spp. against a panel of bacteria capable of causing tuberculosis. After completion of the experiments we concluded that oleoresins are better antimicrobial agents than extracts against evaluated bacteria and may represent a future source for the discovery of new antimycobacterial drugs.
引用
收藏
页数:9
相关论文
共 52 条
  • [1] Antibacterial Effect of Copaifera duckei Dwyer Oleoresin and Its Main Diterpenes against Oral Pathogens and Their Cytotoxic Effect
    Abrao, Fariza
    Alves, Jessica A.
    Andrade, Gessica
    de Oliveira, Pollyanna F.
    Ambrosio, Sergio R.
    Veneziani, Rodrigo C. S.
    Tavares, Denise C.
    Bastos, Jairo K.
    Martins, Carlos H. G.
    [J]. FRONTIERS IN MICROBIOLOGY, 2018, 9
  • [2] Copaifera langsdorffii oleoresin and its isolated compounds: antibacterial effect and antiproliferative activity in cancer cell lines
    Abrao, Fariza
    de Araujo Costa, Luciana Delfino
    Alves, Jacqueline Morais
    Senedese, Juliana Marques
    de Castro, Pamela Tinti
    Ambrosio, Sergio Ricardo
    Sola Veneziani, Rodrigo Cassio
    Bastos, Jairo Kenupp
    Tavares, Denise Crispim
    Martins, Carlos Henrique G.
    [J]. BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2015, 15
  • [3] Achar J., 2017, EMERG INFECT DIS, V15, P23
  • [4] Antimicrobial, Antiproliferative and Proapoptotic Activities of Extract, Fractions and Isolated Compounds from the Stem of Erythroxylum caatingae Plowman
    Aguiar, Jaciana S.
    Araujo, Rosilma O.
    Rodrigues, Maria do Desterro
    Sena, Kesia X. F. R.
    Batista, Andre M.
    Guerra, Maria M. P.
    Oliveira, Steno L.
    Tavares, Josean F.
    Silva, Marcelo S.
    Nascimento, Silene C.
    da Silva, Teresinha Goncalves
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2012, 13 (04): : 4124 - 4140
  • [5] Alvarez C, 2010, BRAZ J INFECT DIS, V14, pS107, DOI 10.1590/S1413-86702010000800006
  • [6] [Anonymous], 2011, Policy statement
  • [7] Determination of in vitro synergy when three antimicrobial agents are combined against Mycobacterium tuberculosis
    Bhusal, Y
    Shiohira, CM
    Yamane, N
    [J]. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2005, 26 (04) : 292 - 297
  • [8] Copaifera duckei Oleoresin and Its Main Nonvolatile Terpenes: In Vitro Schistosomicidal Properties
    Borges, Carly H. G.
    Cruz, Michele G.
    Carneiro, Luiza J.
    da Silva, Jonas J. M.
    Bastos, Jairo K.
    Tavares, Denise C.
    de Oliveira, Pollyanna F.
    Rodrigues, Vanderlei
    Veneziani, Rodrigo C. S.
    Parreira, Renato L. T.
    Caramori, Giovanni F.
    Nagurniak, Glaucio R.
    Magalhaes, Lizandra G.
    Ambrosio, Sergio R.
    [J]. CHEMISTRY & BIODIVERSITY, 2016, 13 (10) : 1348 - 1356
  • [9] Effect of the treatment of Copaifera duckei oleoresin (copaiba) in streptozotocin-induced diabetic rats
    Carvalho, Helison Oliveira
    Ferreira dos Santos, Igor Victor
    da Rocha, Clarice Flexa
    Alves Barros, Albenise Santana
    Faria e Souza, Belmira Silva
    Ferreira, Irlon Maciel
    Bezerra, Roberto Messias
    Lima, Clarissa Silva
    Navarrete Castro, Andres
    Tavares Carvalho, Jose Carlos
    [J]. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, 2018, 28 (06): : 724 - 731
  • [10] Characterization of the chemical composition of oleoresins of Copaifera guianensis Desf., Copaifera duckei Dwyer and Copaifera multijuga Hayne
    Cascon, V
    Gilbert, B
    [J]. PHYTOCHEMISTRY, 2000, 55 (07) : 773 - 778