Environmental Assessment of Enzyme Production and Purification

被引：22

作者：

Becker, Martin ^{[1
]}

Luetz, Stephan ^{[1
]}

Rosenthal, Katrin ^{[1
]}

机构：

[1] TU Dortmund Univ, Dept Biochem & Chem Engn, Chair Bioproc Engn, D-44227 Dortmund, Germany

来源：

MOLECULES | 2021年 / 26卷 / 03期

关键词：

E factor; biocatalysis; green chemistry; cGAS; bioprocess engineering; life cycle assessment; GREEN;

D O I：

10.3390/molecules26030573

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The importance of bioprocesses has increased in recent decades, as they are considered to be more sustainable than chemical processes in many cases. E factors can be used to assess the sustainability of processes. However, it is noticeable that the contribution of enzyme synthesis and purification is mostly neglected. We, therefore, determined the E factors for the production and purification of 10 g enzymes. The calculated complete E factor including required waste and water is 37,835 g(waste)center dot g(enzyme)(-1). This result demonstrates that the contribution of enzyme production and purification should not be neglected for sustainability assessment of bioprocesses.

引用

页数：10

共 29 条

[21] E factors, green chemistry and catalysis: an odyssey [J].

Sheldon, Roger A. .

CHEMICAL COMMUNICATIONS, 2008, (29) :3352-3365

[22] The E factor: fifteen years on [J].

Sheldon, Roger A. .

GREEN CHEMISTRY, 2007, 9 (12) :1273-1283

[23] The Hitchhiker's guide to biocatalysis: recent advances in the use of enzymes in organic synthesis [J].

Sheldon, Roger A. A. ;

Brady, Dean ;

Bode, Moira L. L. .

CHEMICAL SCIENCE, 2020, 11 (10) :2587-2605

[24] The production of fine chemicals by biotransformations [J].

Straathof, AJJ ;

Panke, S ;

Schmid, A .

CURRENT OPINION IN BIOTECHNOLOGY, 2002, 13 (06) :548-556

[25] Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway [J].

Sun, Lijun ;

Wu, Jiaxi ;

Du, Fenghe ;

Chen, Xiang ;

Chen, Zhijian J. .

SCIENCE, 2013, 339 (6121) :786-791

[26] Energising the E-factor: The E+-factor [J].

Tieves, Florian ;

Tonin, Fabio ;

Fernandez-Fueyo, Elena ;

Robbins, John M. ;

Bommarius, Bettina ;

Bommarius, Andreas S. ;

Alcalde, Miguel ;

Hollmann, Frank .

TETRAHEDRON, 2019, 75 (10) :1311-1314

[27] Guidelines and Cost Analysis for Catalyst Production in Biocatalytic Processes [J].

Tufvesson, Par ;

Lima-Ramos, Joana ;

Nordblad, Mathias ;

Woodley, John M. .

ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2011, 15 (01) :266-274

[28] Sustainable and Continuous Synthesis of Enantiopure l-Amino Acids by Using a Versatile Immobilised Multienzyme System [J].

Velasco-Lozano, Susana ;

da Silva, Eunice S. ;

Llop, Jordi ;

Lopez-Gallego, Fernando .

CHEMBIOCHEM, 2018, 19 (04) :395-403

[29] Increasing recombinant protein production in Escherichia coli K12 through metabolic engineering [J].

Waegeman, Hendrik ;

De Lausnay, Stijn ;

Beauprez, Joeri ;

Maertens, Jo ;

De Mey, Marjan ;

Soetaert, Wim .

NEW BIOTECHNOLOGY, 2013, 30 (02) :255-261

← 1 2 3 →