LncRNAs as potential diagnostic and prognostic biomarkers in gastric cancer: A novel approach to personalized medicine

被引：134

作者：

Fattahi, Sadegh ^{[1
,2
,3
]}

Kosari-Monfared, Mohadeseh ^{[4
]}

Golpour, Monireh ^{[5
]}

Emami, Zakieh ^{[4
]}

Ghasemiyan, Mohammad ^{[4
]}

Nour, Maryam ^{[4
]}

Akhavan-Niaki, Haleh ^{[4
]}

机构：

[1] Babol Univ Med Sci, Dept Genet, Student Res Comm, Babol Sar, Iran

[2] Babol Univ Med Sci, Cellular & Mol Biol Res Ctr, Hlth Res Inst, Dept Genet, Babol Sar, Iran

[3] Pasteur Inst, North Res Ctr, Dept Biochem, Amol, Iran

[4] Babol Univ Med Sci, Fac Med, Dept Genet, Babol Sar 4717647745, Iran

[5] Mazandaran Univ Med Sci, Fac Med, Mol & Cell Biol Res Ctr, Dept Immunol,Student Res Comm, Sari, Iran

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2020年 / 235卷 / 04期

关键词：

biomarker; epigenetic; gastric cancer; long noncoding RNAs; personalized medicine; LONG NONCODING RNA; PROMOTES CELL-PROLIFERATION; HELICOBACTER-PYLORI INFECTION; COMPETING ENDOGENOUS RNA; POOR-PROGNOSIS; C-MYC; MESENCHYMAL TRANSITION; MULTIDRUG-RESISTANCE; INCREASED EXPRESSION; PANCREATIC-CANCER;

D O I：

10.1002/jcp.29260

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Gastric cancer is the third leading cause of cancer death with 5-year survival rate of about 30-35%. Since early detection is associated with decreased mortality, identification of novel biomarkers for early diagnosis and proper management of patients with the best response to therapy is urgently needed. Long noncoding RNAs (lncRNAs) due to their high specificity, easy accessibility in a noninvasive manner, as well as their aberrant expression under different pathological and physiological conditions, have received a great attention as potential diagnostic, prognostic, or predictive biomarkers. They may also serve as targets for treating gastric cancer. In this review, we highlighted the role of lncRNAs as tumor suppressors or oncogenes that make them potential biomarkers for the diagnosis and prognosis of gastric cancer. Relatively, lncRNAs such as H19, HOTAIR, UCA1, PVT1, tissue differentiation-inducing nonprotein coding, and LINC00152 could be potential diagnostic and prognostic markers in patients with gastric cancer. Also, the impact of lncRNAs such as ecCEBPA, MLK7-AS1, TUG1, HOXA11-AS, GAPLINC, LEIGC, multidrug resistance-related and upregulated lncRNA, PVT1 on gastric cancer epigenetic and drug resistance as well as their potential as therapeutic targets for personalized medicine was discussed.

引用

页码：3189 / 3206

页数：18

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