The roles of telomeres and telomerase in β-cell regeneration

被引：18
作者：
Liew, C. W.
Holman, A.
Kulkarni, R. N. [1 ]
机构：
[1] Harvard Univ, Sch Med, Joslin Diabet Ctr, Div Res, Boston, MA 02115 USA
来源：
DIABETES OBESITY & METABOLISM | 2009年 / 11卷
关键词：
beta-cells; diabetes; telomere; islets; ageing; PANCREATIC-ISLET CELLS; INSULIN-RESISTANCE; DIABETES-MELLITUS; MAMMALIAN TELOMERES; MOUSE TELOMERASE; UNITED-STATES; BLOOD-CELLS; DNA-DAMAGE; DYSFUNCTION; GROWTH;
D O I：
10.1111/j.1463-1326.2009.01103.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Telomerase is a specialized reverse transcriptase that is responsible for extending and preserving the end of the chromosomes (telomeres). Telomerase plays a key role in regulating the lifespan of mammalian cells and is involved in critical aspects of cellular ageing processes. In this review, we will briefly summarize our current understanding of the functions of telomeres, telomerase and their regulation. Considering that compensatory islet hyperplasia and beta-cell regeneration play important roles in the prevention and/or delay of the onset of overt diabetes, we will also examine current literature regarding the effects of diabetes on telomere shortening and provide insights from our own studies on the role of telomerase in beta-cell regeneration.
引用
收藏
页码：21 / 29
页数：9
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