Scleromyxedema: Successful treatment with thalidomide in two patients

被引：23

作者：

Amini-Adle, Mona ^{[1
]}

Thieulent, Nadege ^{[1
]}

Dalle, Stephane ^{[1
]}

Balme, Brigitte ^{[1
]}

Thomas, Luc ^{[1
]}

机构：

[1] Hop Hotel Dieu, Dept Dermatol, FR-69288 Lyon 02, France

来源：

DERMATOLOGY | 2007年 / 214卷 / 01期

关键词：

scleromyxedema; thalidomide; TNF-alpha;

D O I：

10.1159/000096914

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Background: Scleromyxedema is an unusual skin disease characterized by mucinous infiltration of the skin. There is no satisfactory treatment for this disorder. Case Report: We report 2 cases of scleromyxedema, both associated with an IgG-lambda paraprotein. Treatment with thalidomide was started and great improvement of the lesion was noted as shown by a quality of life questionnaire similar to those used in rheumatoid arthritis. TNF-lambda value was elevated in both cases during this treatment. Discussion: We hypothesize that the efficiency of thalidomide could be mediated by its costimulatory effect on T cytotoxic lymphocytes. Copyright (c) 2007 S. Karger AG, Basel.

引用

页码：58 / 60

页数：3

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