Synthesis and anticonvulsant activity of 1-acetyl-5-arylidenyl-3-(2′-oxo/thiobarbiturinyl)-2-pyrazolines

被引：0

作者：

Archana ^{[1
]}

Srivastava, VK ^{[1
]}

Kumar, A ^{[1
]}

机构：

[1] Lala Lajpat Rai Mem Coll, Dept Pharmacol, Div Med Chem, Meerut 250004, Uttar Pradesh, India

来源：

ARZNEIMITTELFORSCHUNG-DRUG RESEARCH | 2002年 / 52卷 / 11期

关键词：

oxybarbiturinyl derivatives; anticonvulsant activity; chalcones; pyrazolines; rat; synthesis; thiobarbiturinyl derivatives;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

1-(2'-Oxo/thiobarbiturinyl)-3-arylidenylchalcones (3-14) were synthesized by the condensation of different aromatic aldehydes with 5-acetyl-2-oxo/thiobarbituric acid (1 resp. 2) and various 1-acetyl-5-arylidenyl-3-(2'-oxo/ thiobarbiturinyl)-2-pyrazolines (15-26) were synthesized by cyclisation of compounds 3-14 with hydrazine hydrate. The newly synthesized compounds showed anticonvulsant activity ranging from 40% to 90%. Compound 23 showed the maximum activity being more potent than the reference drug 1-acetyl-5-(P-methoxyphenyl)-3-(2'-thiobarbiturinyl)-2-pyrazoline.

引用

页码：787 / 791

页数：5

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