Oligomerization of Cry11Aa from Bacillus thuringiensis Has an Important Role in Toxicity against Aedes aegypti

被引：22
|
作者：
Munoz-Garay, Carlos [1 ]
Rodriguez-Almazan, Claudia [1 ]
Aguilar, Jose N. [1 ]
Portugal, Leivi [1 ]
Gomez, Isabel [1 ]
Saab-Rincon, Gloria [1 ]
Soberon, Mario [1 ]
Bravo, Alejandra [1 ]
机构：
[1] Univ Nacl Autonoma Mexico, Inst Biotecnol, Cuernavaca 62250, Morelos, Mexico
来源：
APPLIED AND ENVIRONMENTAL MICROBIOLOGY | 2009年 / 75卷 / 23期
关键词：
CIRCULAR-DICHROISM SPECTRA; PRE-PORE; CULEX-QUINQUEFASCIATUS; SECONDARY STRUCTURE; SUBSP ISRAELENSIS; CRYSTAL PROTEINS; CRY1AB TOXIN; CYTA; RECEPTOR; CRYIVD;
D O I：
10.1128/AEM.01303-09
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Cry11Aa and Cyt1Aa of Bacillus thuringiensis are active against mosquitoes and show synergism. Cyt1Aa functions as a membrane receptor inducing Cry11Aa oligomerization. Here we characterized Cry11Aa helix alpha-3 mutants impaired in oligomerization and toxicity against Aedes aegypti, indicating that oligomerization of Cry11Aa is important for toxin action. Cyt1Aa did not recover the insecticidal activity of Cry11Aa mutants.
引用
收藏
页码：7548 / 7550
页数：3
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