True vocal fold nodules: the role of differential diagnosis

Purpose of review The present article aims to discuss the current reviews and the literature published regarding the differential diagnosis of vocal fold nodules with emphasis on diagnosis and nomenclature. Recent findings Benign lesions of the vocal folds, including nodules, continue to challenge practitioners in nomenclature uniformity and even histologic diagnosis. Utilization of molecular techniques is helping to better understand Reinke's space and to better differentiate these lesions. This more accurate diagnosis may help guide appropriate treatment indicating behavioral versus surgical therapy. Summary Further study with the application of new technology in the laboratory and clinic will continue to refine our differential diagnosis and understanding of vocal fold nodules.