Simultaneous determination of guanosine and guanosine-5′-triphosphate in biological sample using gold nanoparticles modified indium tin oxide electrode

被引：35

作者：

Goyal, Rajendra N. ^{[1
]}

Oyama, Munetaka

Tyagi, Anuradha

机构：

[1] Indian Inst Technol, Dept Chem, Roorkee 247667, Uttar Pradesh, India

[2] Int Innovat Ctr, Div Res Initiat, Nishikyo Ku, Kyoto 6158520, Japan

来源：

ANALYTICA CHIMICA ACTA | 2007年 / 581卷 / 01期

基金：

日本学术振兴会;

关键词：

nanogold modified indium tin oxide electrode; guanosine; guanosine-5 '-triphosphate; differential pulse voltammetry; blood sample;

D O I：

10.1016/j.aca.2006.08.012

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A nanogold modified indium tin oxide (ITO) electrode was used for the simultaneous determination of guanosine and GTP at pH 7.2. The electrode exhibited an effective catalytic response towards their oxidation and lowered the oxidation potential of guanosine by similar to 120 mV and GTP by similar to 183 mV Linear concentration curves were obtained for guanosine with a detection limit of 9.8 x 10(-8) M and 5.5 x 10(-8) M for GTR The concentration of guanosine and GTP were also estimated in the human blood plasma samples using gold nanoparticles modified ITO electrode with good reproducibility. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：32 / 36

页数：5

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