Mechanoenzymatic peptide and amide bond formation

被引：81

作者：

Hernandez, Jose G. ^{[1
]}

Ardila-Fierro, Karen J. ^{[1
]}

Crawford, Deborah ^{[2
]}

James, Stuart L. ^{[2
,3
]}

Bolm, Carsten ^{[1
]}

机构：

[1] Rhein Westfal TH Aachen, Inst Organ Chem, Landoltweg 1, D-52074 Aachen, Germany

[2] Queens Univ Belfast, Sch Chem & Chem Engn, David Keir Bldg,Stranmillis Rd, Belfast BT9 5AG, Antrim, North Ireland

[3] MOF Technol Ltd, 63 Univ Rd, Belfast BT7 1NF, Antrim, North Ireland

来源：

GREEN CHEMISTRY | 2017年 / 19卷 / 11期

基金：

英国工程与自然科学研究理事会;

关键词：

SOLVENT-FREE CONDITIONS; PROTECTED AMINO-ACIDS; BALL MILL; ASYMMETRIC ORGANOCATALYSIS; ORGANIC-REACTIONS; CARBOXYLIC-ACIDS; ALDOL REACTION; MECHANOCHEMISTRY; MECHANOSYNTHESIS; DIPEPTIDES;

D O I：

10.1039/c7gc00615b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Mechanochemical chemoenzymatic peptide and amide bond formation catalysed by papain was studied by ball milling. Despite the high-energy mixing experienced inside the ball mill, the biocatalyst proved stable and highly efficient to catalyse the formation of alpha, alpha- and alpha, beta-dipeptides. This strategy was further extended to the enzymatic acylation of amines by milling, and to the mechanosynthesis of a derivative of the valuable dipeptide L-alanyl-L-glutamine.

引用

页码：2620 / 2625

页数：6

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