Education differentially contributes to cognitive reserve across racial/ethnic groups

被引：86

作者：

Avila, Justina F. ^{[1
]}

Renteria, Miguel Arce ^{[2
,3
,4
]}

Jones, Richard N. ^{[5
]}

Vonk, Jet M. J. ^{[2
,3
,4
,6
,7
]}

Turney, Indira ^{[2
,3
,4
]}

Sol, Ketlyne ^{[8
]}

Seblova, Dominika ^{[2
,3
,4
]}

Arias, Franchesca ^{[9
]}

Hill-Jarrett, Tanisha ^{[10
]}

Levy, Shellie-Anne ^{[11
]}

Meyer, Oanh ^{[12
]}

Racine, Annie M. ^{[13
]}

Tom, Sarah E. ^{[3
,4
,14
]}

Melrose, Rebecca J. ^{[15
]}

Deters, Kacie ^{[16
]}

Medina, Luis D. ^{[17
]}

Carrion, Carmen, I ^{[18
]}

Diaz-Santos, Mirella ^{[19
]}

Byrd, DeAnnah R. ^{[20
]}

Chesebro, Anthony ^{[2
,3
,4
]}

Colon, Juliet ^{[2
,3
,4
]}

Igwe, Kay C. ^{[2
,3
,4
]}

Maas, Benjamin ^{[2
,3
,4
]}

Brickman, Adam M. ^{[2
,3
,4
]}

Schupf, Nicole ^{[2
,3
,4
]}

Mayeux, Richard ^{[2
,3
,4
]}

Manly, Jennifer J. ^{[2
,3
,4
]}

机构：

[1] Univ New Mexico, Dept Psychol, Albuquerque, NM 87131 USA

[2] Columbia Univ, Coll Phys & Surg, Taub Inst Res Alzheimers Dis & Aging Brain, New York, NY 10032 USA

[3] Columbia Univ, Coll Phys & Surg, Gertrude H Sergievsky Ctr, New York, NY 10032 USA

[4] Columbia Univ, Coll Phys & Surg, Dept Neurol, New York, NY 10032 USA

[5] Brown Univ, Butler Hosp, Warren Alpert Med Sch, Dept Neurol, Providence, RI 02912 USA

[6] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Dept Epidemiol, Utrecht, Netherlands

[7] Univ Utrecht, Utrecht, Netherlands

[8] Univ Michigan, Dept Psychol, Ann Arbor, MI USA

[9] Harvard Med Sch Affiliate, Aging Brain Ctr, Hebrew Senior Life, Boston, MA USA

[10] Univ S Florida, Dept Neurosurg, Tampa, FL 33620 USA

[11] Univ Florida, Dept Clin & Hlth Psychol, Gainesville, FL USA

[12] Univ Calif Davis, Sch Med, Dept Neurol, Sacramento, CA 95817 USA

[13] Biogen Inc, 14 Cambridge Ctr, Cambridge, MA 02142 USA

[14] Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY USA

[15] VA Greater Los Angeles Healthcare Syst, Los Angeles, CA USA

[16] Stanford Univ, Dept Neurol & Neurol Sci, Sch Med, Stanford, CA 94305 USA

[17] Univ Houston, Dept Psychol, Houston, TX USA

[18] Yale Univ, Sch Med, Dept Neurol, New Haven, CT 06510 USA

[19] Univ Calif Los, Dept Psychiat & Biobehav Sci, Angeles, CA USA

[20] Wayne State Univ, Inst Gerontol, Detroit, MI 48202 USA

来源：

ALZHEIMERS & DEMENTIA | 2021年 / 17卷 / 01期

关键词：

cognitive aging; cognitive reserve; education; racial/ethnic differences;

D O I：

10.1002/alz.12176

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

IntroductionWe examined whether educational attainment differentially contributes to cognitive reserve (CR) across race/ethnicity. Methods: A total of 1553 non-Hispanic Whites (Whites), non-Hispanic Blacks (Blacks), and Hispanics in the Washington Heights-Inwood Columbia Aging Project (WHICAP) completed structural magnetic resonance imaging. Mixture growth curve modeling was used to examine whether the effect of brain integrity indicators (hippocampal volume, cortical thickness, and white matter hyperintensity [WMH] volumes) on memory and language trajectories was modified by education across racial/ethnic groups. Results: Higher educational attainment attenuated the negative impact of WMH burden on memory (beta = -0.03; 99% CI: -0.071, -0.002) and language decline (beta = -0.024; 99% CI:- 0.044, -0.004), as well as the impact of cortical thinning on level of language performance for Whites, but not for Blacks or Hispanics. Discussion: Educational attainment does not contribute to CR similarly across racial/ethnic groups.

引用

页码：70 / 80

页数：11

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