substance use disorder;
cannabis;
externalising disorders;
anxiety;
depression;
epidemiology;
D O I:
10.1016/j.drugalcdep.2006.12.013
中图分类号:
R194 [卫生标准、卫生检查、医药管理];
学科分类号:
摘要:
Background: Whereas the role of externalizing disorders is relatively well established in predicting the onset of cannabis use (CU) or cannabis use disorder (CUD), the status of anxiety and mood disorders in predicting CU and CUD remains controversial. Objective: (1) To examine cross-sectional and prospective associations of CU and CUD with a range of mental disorders and whether anxiety and mood disorders are associated with CU/CUD after adjusting for externalizing disorders. Methods: N = 1395 community subjects aged 14-17 at baseline were followed-up at three waves prospectively over 10 years. Substance use, substance disorders and mental disorders were assessed using the DSM-IV/M-CIDI. Results: (1) The baseline prevalence rates where 19.3% at t(0) for CU and 2.6% for CUD. Cumulative incidence rates at t(3) were 54.3% for CU and 13.7% for CUD. (2) In cross-sectional and prospective analyses other substance use disorders, mood and anxiety disorders were associated with CU and CUD. (3) Associations of panic-anxiety with CU and of depressive and bipolar disorders with CU and CUD were significant after controlling for externalizing disorders. Conclusion: A range of psychopathological conditions, including depressive, bipolar and less consistently anxiety disorders as well as the degree of their comorbidity are significantly associated with incident CU and progression to CUD, even when controlling for externalising disorders. A better understanding of this complex interplay may result in better aetiological models and intervention strategies. (c) 2007 Published by Elsevier Ireland Ltd.
机构:
University of Sao Paulo-Ribeirao Preto Medical School, Ribeirao Preto, Sao PauloUniversity of Sao Paulo-Ribeirao Preto Medical School, Ribeirao Preto, Sao Paulo
Halah M.P.
Zochniak M.P.
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机构:
Addictions Division, Centre for Addiction and Mental Health (CAMH), 100 Stokes Street, BGB 3288, Toronto, M6J 1H4, ONUniversity of Sao Paulo-Ribeirao Preto Medical School, Ribeirao Preto, Sao Paulo
Zochniak M.P.
Barr M.S.
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机构:
Addictions Division, Centre for Addiction and Mental Health (CAMH), 100 Stokes Street, BGB 3288, Toronto, M6J 1H4, ON
Department of Psychiatry, Division of Brain and Therapeutics, University of Toronto, Toronto, ONUniversity of Sao Paulo-Ribeirao Preto Medical School, Ribeirao Preto, Sao Paulo
Barr M.S.
George T.P.
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机构:
Addictions Division, Centre for Addiction and Mental Health (CAMH), 100 Stokes Street, BGB 3288, Toronto, M6J 1H4, ON
Department of Psychiatry, Division of Brain and Therapeutics, University of Toronto, Toronto, ONUniversity of Sao Paulo-Ribeirao Preto Medical School, Ribeirao Preto, Sao Paulo
机构:
Univ Jaume 1, Fac Ciencias Humanas & Sociales, Dept Psicol Basica Clin & Psicobiol, Castellon de La Plana, SpainUniv Jaume 1, Fac Ciencias Humanas & Sociales, Dept Psicol Basica Clin & Psicobiol, Castellon de La Plana, Spain
机构:
Univ New S Wales, Natl Drug & Alcohol Res Ctr, Sydney, NSW 2052, AustraliaUniv New S Wales, Natl Drug & Alcohol Res Ctr, Sydney, NSW 2052, Australia
Teesson, Maree
Slade, Tim
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Univ New S Wales, Natl Drug & Alcohol Res Ctr, Sydney, NSW 2052, AustraliaUniv New S Wales, Natl Drug & Alcohol Res Ctr, Sydney, NSW 2052, Australia
Slade, Tim
Swift, Wendy
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Univ New S Wales, Natl Drug & Alcohol Res Ctr, Sydney, NSW 2052, AustraliaUniv New S Wales, Natl Drug & Alcohol Res Ctr, Sydney, NSW 2052, Australia
Swift, Wendy
Mills, Katherine
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Univ New S Wales, Natl Drug & Alcohol Res Ctr, Sydney, NSW 2052, AustraliaUniv New S Wales, Natl Drug & Alcohol Res Ctr, Sydney, NSW 2052, Australia
Mills, Katherine
Memedovic, Sonja
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Univ New S Wales, Natl Drug & Alcohol Res Ctr, Sydney, NSW 2052, AustraliaUniv New S Wales, Natl Drug & Alcohol Res Ctr, Sydney, NSW 2052, Australia
Memedovic, Sonja
Mewton, Louise
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Univ New S Wales, Natl Drug & Alcohol Res Ctr, Sydney, NSW 2052, AustraliaUniv New S Wales, Natl Drug & Alcohol Res Ctr, Sydney, NSW 2052, Australia
Mewton, Louise
Grove, Rachel
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Univ New S Wales, Natl Drug & Alcohol Res Ctr, Sydney, NSW 2052, AustraliaUniv New S Wales, Natl Drug & Alcohol Res Ctr, Sydney, NSW 2052, Australia
Grove, Rachel
Newton, Nicola
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Univ New S Wales, Natl Drug & Alcohol Res Ctr, Sydney, NSW 2052, AustraliaUniv New S Wales, Natl Drug & Alcohol Res Ctr, Sydney, NSW 2052, Australia
Newton, Nicola
Hall, Wayne
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机构:
Univ Queensland, Clin Res Ctr, Brisbane, Qld 4072, AustraliaUniv New S Wales, Natl Drug & Alcohol Res Ctr, Sydney, NSW 2052, Australia
机构:
St Josephs Healthcare Hamilton, Anxiety Treatment & Res Clin, Hamilton, ON, Canada
McMaster Univ, Dept Psychol Neurosci & Behav, Hamilton, ON, CanadaSt Josephs Healthcare Hamilton, Anxiety Treatment & Res Clin, Hamilton, ON, Canada
Ouellette, Melise J.
Rowa, Karen
论文数: 0引用数: 0
h-index: 0
机构:
St Josephs Healthcare Hamilton, Anxiety Treatment & Res Clin, Hamilton, ON, Canada
McMaster Univ, Dept Psychol Neurosci & Behav, Hamilton, ON, Canada
McMaster Univ, Dept Psychiat & Behav Neurosci, Hamilton, ON, CanadaSt Josephs Healthcare Hamilton, Anxiety Treatment & Res Clin, Hamilton, ON, Canada
Rowa, Karen
Cameron, Duncan H.
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h-index: 0
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St Josephs Healthcare Hamilton, Anxiety Treatment & Res Clin, Hamilton, ON, CanadaSt Josephs Healthcare Hamilton, Anxiety Treatment & Res Clin, Hamilton, ON, Canada
Cameron, Duncan H.
Elcock, Ashleigh
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h-index: 0
机构:
St Josephs Healthcare Hamilton, Anxiety Treatment & Res Clin, Hamilton, ON, CanadaSt Josephs Healthcare Hamilton, Anxiety Treatment & Res Clin, Hamilton, ON, Canada
Elcock, Ashleigh
Soreni, Noam
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h-index: 0
机构:
St Josephs Healthcare Hamilton, Anxiety Treatment & Res Clin, Hamilton, ON, Canada
McMaster Univ, Dept Psychiat & Behav Neurosci, Hamilton, ON, CanadaSt Josephs Healthcare Hamilton, Anxiety Treatment & Res Clin, Hamilton, ON, Canada
Soreni, Noam
Pawluk, Elizabeth J.
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机构:
St Josephs Healthcare Hamilton, Anxiety Treatment & Res Clin, Hamilton, ON, Canada
McMaster Univ, Dept Psychiat & Behav Neurosci, Hamilton, ON, CanadaSt Josephs Healthcare Hamilton, Anxiety Treatment & Res Clin, Hamilton, ON, Canada
Pawluk, Elizabeth J.
McCabe, Randi E.
论文数: 0引用数: 0
h-index: 0
机构:
St Josephs Healthcare Hamilton, Anxiety Treatment & Res Clin, Hamilton, ON, Canada
McMaster Univ, Dept Psychol Neurosci & Behav, Hamilton, ON, Canada
McMaster Univ, Dept Psychiat & Behav Neurosci, Hamilton, ON, CanadaSt Josephs Healthcare Hamilton, Anxiety Treatment & Res Clin, Hamilton, ON, Canada