Auto-antibodies to type I IFNs can underlie adverse reactions to yellow fever live attenuated vaccine

被引：163

作者：

Bastard, Paul ^{[1
,2
,3
]}

Michailidis, Eleftherios ^{[4
]}

Hoffmann, Hans-Heinrich ^{[4
]}

Chbihi, Marwa ^{[1
,2
]}

Le Voyer, Tom ^{[1
,2
]}

Rosain, Jeremie ^{[1
,2
]}

Philippot, Quentin ^{[1
,2
]}

Seeleuthner, Yoann ^{[1
]}

Gervais, Adrian ^{[1
,2
]}

Materna, Marie ^{[1
,2
]}

Nunes de Oliveira, Patricia Mouta ^{[5
]}

Maia, Maria de Lourdes S. ^{[5
]}

Ano Bom, Ana Paula Dinis ^{[6
]}

Azamor, Tamiris ^{[6
]}

da Conceicao, Deborah Araujo ^{[5
]}

Goudouris, Ekaterini ^{[7
]}

Homma, Akira ^{[5
]}

Slesak, Gunther ^{[8
]}

Schaefer, Johannes ^{[8
]}

Pulendran, Bali ^{[9
,10
,11
]}

Miller, Joseph D. ^{[9
,10
,12
]}

Huits, Ralph ^{[13
]}

Yang, Rui ^{[3
]}

Rosen, Lindsey B. ^{[14
]}

Bizien, Lucy ^{[1
,2
]}

Lorenzo, Lazaro ^{[1
,2
]}

Chrabieh, Maya ^{[1
,2
]}

Erazo, Lucia, V ^{[1
]}

Rozenberg, Flore ^{[15
]}

Jeljeli, Mohamed Maxime ^{[16
]}

Beziat, Vivien ^{[1
,2
,3
]}

Holland, Steven M. ^{[14
]}

Cobat, Aurelie ^{[1
,3
]}

Notarangelo, Luigi D. ^{[14
]}

Su, Helen C. ^{[14
]}

Ahmed, Rafi ^{[9
,10
]}

Puel, Anne ^{[1
,2
,3
]}

Zhang, Shen-Ying ^{[1
,2
,3
]}

Abel, Laurent ^{[1
,2
,3
]}

Seligman, Stephen J. ^{[3
,17
]}

Zhang, Qian ^{[3
]}

MacDonald, Margaret R. ^{[4
]}

Jouanguy, Emmanuelle ^{[1
,2
,3
]}

Rice, Charles M. ^{[4
]}

Casanova, Jean-Laurent ^{[1
,2
,3
,18
]}

机构：

[1] Necker Hosp Sick Children, Inst Natl Sante & Rech Med U1163, Necker Branch, Lab Human Genet Infect Dis, Paris, France

[2] Univ Paris, Imagine Inst, Paris, France

[3] Rockefeller Univ, Rockefeller Branch, St Giles Lab Human Genet Infect Dis, 1230 York Ave, New York, NY 10021 USA

[4] Rockefeller Univ, Lab Virol & Infect Dis, New York, NY 10021 USA

[5] Minist Hlth, FIOCRUZ, Biomanguinhos, Rio De Janeiro, Brazil

[6] Minist Hlth, Lab Immunol Tech, FIOCRUZ, Biomanguinhos, Rio De Janeiro, Brazil

[7] Univ Fed Rio de Janeiro, Rio De Janeiro, Brazil

[8] Tropenklin Paul Lechler Krankenhaus, Trop Med Dept, Tubingen, Germany

[9] Emory Univ, Emory Vaccine Ctr, Sch Med, Atlanta, GA USA

[10] Emory Univ, Sch Med, Dept Microbiol & Immunol, Atlanta, GA 30322 USA

[11] Stanford Univ, Dept Pathol, Dept Microbiol & Immunol, Inst Immun Transplantat & Infect, Stanford, CA 94305 USA

[12] Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Div Sci Resources, Atlanta, GA USA

[13] Inst Trop Med, Dept Clin Sci, Antwerp, Belgium

[14] NIAID, Lab Clin Immunol & Microbiol, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA

[15] Univ Paris, Cochin Hosp, AP HP, Lab Virol, Paris, France

[16] Univ Paris, Cochin Hosp, AP HP, Lab Immunol, Paris, France

[17] New York Med Coll, Valhalla, NY 10595 USA

[18] Howard Hughes Med Inst, New York, NY 10065 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2021年 / 218卷 / 04期

关键词：

VISCEROTROPIC DISEASE; DISTINCT FUNCTIONS; INTERFERON; DEFICIENCY; MYCOBACTERIAL; ANTIBODIES; FRAMEWORK; PATIENT; SAFETY;

D O I：

10.1084/jem.20202486

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Yellow fever virus (YFV) live attenuated vaccine can, in rare cases, cause life-threatening disease, typically in patients with no previous history of severe viral illness. Autosomal recessive (AR) complete IFNAR1 deficiency was reported in one 12-yr-old patient. Here, we studied seven other previously healthy patients aged 13 to 80 yr with unexplained life-threatening YFV vaccine-associated disease. One 13-yr-old patient had AR complete IFNAR2 deficiency. Three other patients vaccinated at the ages of 47, 57, and 64 yr had high titers of circulating auto-Abs against at least 14 of the 17 individual type I IFNs. These antibodies were recently shown to underlie at least 10% of cases of life-threatening COVID-19 pneumonia. The auto-Abs were neutralizing in vitro, blocking the protective effect of IFN-?2 against YFV vaccine strains. AR IFNAR1 or IFNAR2 deficiency and neutralizing auto-Abs against type I IFNs thus accounted for more than half the cases of life-threatening YFV vaccine-associated disease studied here. Previously healthy subjects could be tested for both predispositions before anti-YFV vaccination.

引用

页数：16

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