Malignant craniopharyngioma; case report and review of the literature

被引：25

作者：

Boongird, Atthaporn ^{[1
]}

Laothamatas, Jiraporn ^{[2
]}

Larbcharoensub, Noppadol ^{[3
]}

Phudhichareonrat, Suchart ^{[4
]}

机构：

[1] Mahidol Univ, Dept Surg, Ramathibodi Hosp, Fac Med, Bangkok 10400, Thailand

[2] Mahidol Univ, Dept Radiol, Ramathibodi Hosp, Fac Med, Bangkok 10400, Thailand

[3] Mahidol Univ, Dept Pathol, Ramathibodi Hosp, Fac Med, Bangkok 10400, Thailand

[4] Prasat Neurol Inst, Dept Pathol, Bangkok, Thailand

来源：

NEUROPATHOLOGY | 2009年 / 29卷 / 05期

关键词：

adamantinomatous pattern; anaplastic; malignant craniopharyngioma; suprasellar region;

D O I：

10.1111/j.1440-1789.2008.00986.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A case of malignant craniopharyngioma in a 46-year-old woman presenting clinically with visual disturbance and bifrontal headache is reported. Histopathologic examination of the suprasellar mass showed a lesion characterized by nests of epithelial cells with a basaloid appearance, round-to-oval nuclei, moderate pleomorphism, hyperchromasia, increased nuclear cytoplastic ratio and high mitotic activity. Immunohistochemically, the tumor cells were positive for Ki-67 (44.3%), p53 (98%), and p63 (100%), but negative for estrogen and progesterone receptors. Clinical and pathologic features with a brief review of the relevant literature for malignant craniopharyngioma as a novel member of tumors of the suprasellar region, is discussed.

引用

页码：591 / 596

页数：6

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