Why Argonaute is needed to make microRNA target search fast and reliable

被引：32
作者：
Klein, Misha
Chandradoss, Stanley D.
Depken, Martin [1 ]
Joo, Chirlmin [1 ]
机构：
[1] Delft Univ Technol, Kavli Inst NanoSci, NL-2629 HZ Delft, Netherlands
来源：
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2017年 / 65卷
基金：
欧洲研究理事会;
关键词：
Argonaute; miRNA; Target Search; Lateral diffusion; Single molecule; FRET; Free-energy landscape; Theoretical model; RNA silencing; Search stability paradox; MicroRNA target prediction; FACILITATED DIFFUSION; BINDING-PROPERTIES; MISMATCH REPAIR; DNA INTERACTION; CRISPR RNA; PROTEIN; COMPLEX; RECOGNITION; MODEL; GUIDE;
D O I：
10.1016/j.semcdb.2016.05.017
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
MicroRNA (miRNA) interferes with the translation of cognate messenger RNA (mRNA) by finding, preferentially binding, and marking it for degradation. To facilitate the search process, Argonaute (Ago) proteins come together with miRNA, forming a dynamic search complex. In this review we use the language of free-energy landscapes to discuss recent single-molecule and high-resolution structural data in the light of theoretical work appropriated from the study of transcription-factor search. We suggest that experimentally observed internal states of the Ago-miRNA search complex may have the explicit biological function of speeding up search while maintaining specificity. (C) 2016 The Authors. Published by Elsevier Ltd.
引用
收藏
页码：20 / 28
页数：9
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