Highly Enantioselective Cobalt-Catalyzed (3+2) Cycloadditions of Alkynylidenecyclopropanes

被引：22

作者：

Da Concepcion, Eduardo ^{[1
,2
]}

Fernandez, Israel ^{[3
,4
]}

Mascarenas, Jose L. ^{[1
,2
]}

Lopez, Fernando ^{[1
,2
,5
]}

机构：

[1] Univ Santiago de Compostela, Ctr Singular Invest Quim Biol & Mat Mol CiQUS, Santiago De Compostela 15782, Spain

[2] Univ Santiago de Compostela, Dept Quim Organ, Santiago De Compostela 15782, Spain

[3] Univ Complutense Madrid, Fac Ciencias Quim, Dept Quim Organ 1, Madrid 28040, Spain

[4] Univ Complutense Madrid, Fac Ciencias Quim, Ctr Innovac Quim Avanzada ORFEO CINQA, Madrid 28040, Spain

[5] CSIC, Mision Biol Galicia, Pontevedra 36080, Spain

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2021年 / 60卷 / 15期

关键词：

alkylidenecyclopropane; cobalt; cycloaddition; earth-abundant metals; enantioselectivity;

D O I：

10.1002/anie.202015202

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Low-valent cobalt complexes equipped with chiral ligands can efficiently promote highly enantioselective (3+2) cycloadditions of alkyne-tethered alkylidenecyclopropanes. The annulation allows to assemble bicyclic systems containing five-membered rings in good yields and with excellent enantiomeric ratios. We also present a mechanistic discussion based on experimental and computational data, which support the involvement of Co-I/Co-III catalytic cycles.

引用

页码：8182 / 8188

页数：7

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