Influence of the dissolution solvent on the cytotoxicity of octahedral cationic Ir(III) hydride complexes

被引：19

作者：

Huang, Huaiyi ^{[1
,2
]}

Humbert, Nicolas ^{[3
]}

Bizet, Vincent ^{[3
]}

Patra, Malay ^{[1
]}

Chao, Hui ^{[2
]}

Mazet, Clement ^{[3
]}

Gasser, Gilles ^{[4
]}

机构：

[1] Univ Zurich, Dept Chem, Winterthurerstr 190, CH-8057 Zurich, Switzerland

[2] Sun Yat Sen Univ, Sch Chem, MOE, Key Lab Bioinorgan & Synthet Chem, Guangzhou 510275, Guangdong, Peoples R China

[3] Univ Geneva, Dept Organ Chem, Quai Ernest Ansermet 30, CH-1211 Geneva, Switzerland

[4] PSL Res Univ, Chim ParisTech, Lab Inorgan Chem Biol, F-75005 Paris, France

来源：

JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2017年 / 839卷

基金：

美国国家科学基金会; 瑞士国家科学基金会;

关键词：

Bioorganometallic chemistry; Dimethyl formamide; Dimethyl sulfoxide; Iridium; Ligand exchange; Medicinal organometallic chemistry; Stability; METAL OXIDE CLUSTERS; SOLID-STATE CHEMISTRY; ORGANOMETALLIC COMPOUNDS; ANTICANCER AGENTS; IRIDIUM(III); RHODIUM(I); DIMETHYLSULFOXIDE; ISOMERIZATION; PLATINUM(II); COBALT(III);

D O I：

10.1016/j.jorganchem.2016.12.010

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The stability of a compound in the solvent in which it is dissolved is a fundamental parameter in medicinal chemistry. In this article, we report on the results of our investigations on the stability of five Ir(III) complexes in DMF and DMSO. Importantly, we demonstrate that the rate of ligand exchange/decomposition of these compounds has an influence on their in vitro anticancer properties. The compounds were generally found to be less toxic to cancer cells after having been dissolved for longer time (24 h) in DMSO compared to short incubation time (1 h) in the same solvent. On the contrary, only minor differences in cytotoxicity were observed when the compounds were dissolved in DMF, emphasizing that this solvent should be employed instead of DMSO when unstable compounds are investigated, provided that the concentration of DMF is kept at a low concentration level. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：15 / 18

页数：4

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