Invariant natural killer T cells: Not to be ignored in liver disease

被引：8
作者：
Gan, Jian [1 ]
Mao, Xiao Rong [1 ,2 ]
Zheng, Su Jun [3 ]
Li, Jun Feng [1 ,2 ,4 ]
机构：
[1] Lanzhou Univ, Clin Med Coll 1, 1 Donggangxi Rd, Lanzhou 730000, Gansu, Peoples R China
[2] Lanzhou Univ, Hosp 1, Dept Infect Dis, 1 Donggangxi Rd, Lanzhou 730000, Gansu, Peoples R China
[3] Capital Med Univ, Beijing YouAn Hosp, Artificial Liver Ctr, Beijing, Peoples R China
[4] Lanzhou Univ, Hosp 1, Inst Infect Dis, 1 Donggangxi Rd, Lanzhou 730000, Gansu, Peoples R China
来源：
JOURNAL OF DIGESTIVE DISEASES | 2021年 / 22卷 / 03期
基金：
中国国家自然科学基金;
关键词：
hepatitis; hepatocellular carcinoma; invariant natural killer T‐ cells; liver fibrosis; liver injury;
D O I：
10.1111/1751-2980.12968
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
The liver is an important immune organ. Hepatocellular injury can be caused by many factors, which further leads to chronic liver diseases by activating the immune system. Multiple immune cells, such as T lymphocytes, B lymphocytes, natural killer cells (NKs), natural killer T cells (NKTs), and gamma delta T cells, accumulate and participate in the immune regulation of the liver. NKTs are an indispensable component of immune cells in the liver, and invariant natural killer T cells (iNKTs) are the main subpopulation of NKTs. iNKTs activated by glycolipid antigen presented on CD1d secrete a series of cytokines and also act on other immune cells through cell-to-cell contact. Studies on the relationship between iNKTs and liver immunity have provided clues to uncover the pathogenesis of liver diseases and develop a promising strategy for the diagnosis and treatment of liver diseases.
引用
收藏
页码：136 / 142
页数：7
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