Antihistamines are superior to topical steroids in managing Human Immunodeficiency Virus (HIV)-associated papular pruritic eruption

被引：7

作者：

Navarini, Alexander A. ^{[1
,2
]}

Stoeckle, Marcel ^{[1
,4
]}

Navarini, Susanne ^{[1
,5
]}

Mossdorf, Erik ^{[1
,4
]}

Jullu, Boniphace S. ^{[1
]}

Mchomvu, Rehema ^{[1
]}

Mbata, Marco ^{[3
]}

Kibatala, Patience ^{[3
]}

Tanner, Marcel ^{[4
]}

Hatz, Christoph ^{[4
]}

Schmid-Grendelmeier, Peter ^{[2
]}

机构：

[1] Ifakara Hlth Inst, Ifakara, Kilombero, Tanzania

[2] Univ Zurich Hosp, Dept Dermatol, CH-8091 Zurich, Switzerland

[3] St Francis Dist Designated Hosp, Ifakara, Kilombero, Tanzania

[4] Swiss Trop Inst, CH-4002 Basel, Switzerland

[5] Univ Hosp Bern, Dept Pediat, CH-3010 Bern, Switzerland

来源：

INTERNATIONAL JOURNAL OF DERMATOLOGY | 2010年 / 49卷 / 01期

关键词：

HIV-INFECTION;

D O I：

10.1111/j.1365-4632.2009.04279.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Papular pruritic eruption (PPE) is a frequent HIV-comorbidity in tropical countries. Because of constant itching and social stigma, effective treatment is highly valued. In our HIV cohort in rural Tanzania with 12% prevalence of PPE, we have retrospectively analyzed responses to available treatments. Oral promethazine improved itching (P < 0.0058) and clinical scores (P < 0.032) significantly more than topical steroids. Disease activity did not correlate with CD4+ and CD8+ T cell counts and was independent of anti-retroviral medication. Therefore, oral antihistamines are an effective first-line treatment for PPE.

引用

页码：83 / 86

页数：4

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