Sustainable Carbene Transfer Reactions with Iron and Light

被引：59
作者：
Empel, Claire [1 ]
Koenigs, Rene M. [1 ]
机构：
[1] Rhein Westfal TH Aachen, Inst Organ Chem, Landoltweg 1, D-52074 Aachen, Germany
来源：
SYNLETT | 2019年 / 30卷 / 17期
关键词：
carbene transfer reactions; cycloaddition; rearrangement; C-H functionalization; diazoalkanes; iron; photochemistry; KIRMSE REARRANGEMENT REACTIONS; CATALYZED CYCLOPROPANATION; CYCLOADDITION; INHIBITOR; PORPHYRIN; INSERTION; MEDIA;
D O I：
10.1055/s-0037-1611874
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Carbenes are versatile, highly reactive intermediates with great importance in chemistry. We recently reported on our findings on safe and scalable applications of hazardous diazoacetonitrile using cheap and commercially available iron catalysts in efficient carbene transfer reactions, ranging from cyclopropanation towards C-H functionalization reactions for the synthesis of biologically important building blocks. More lately, we uncovered the reactivity of diazoalkanes under photochemical conditions using visible light and were able to demonstrate a variety of different, metal-free carbene transfer reactions, which now open up new sustainable ways for the construction of small functional molecules.
引用
收藏
页码：1929 / 1934
页数：6
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