Targeting macrophages in cancer immunotherapy

被引：445

作者：

Duan, Zhaojun ^{[1
,2
,3
]}

Luo, Yunping ^{[1
,2
,3
]}

机构：

[1] Chinese Acad Med Sci, Inst Basic Med Sci, Dept Immunol, Beijing, Peoples R China

[2] Peking Union Med Coll, Sch Basic Med, Beijing, Peoples R China

[3] Chinese Acad Med Sci, Inst Basic Med Sci, Collaborat Innovat Ctr Biotherapy, Beijing, Peoples R China

来源：

SIGNAL TRANSDUCTION AND TARGETED THERAPY | 2021年 / 6卷 / 01期

基金：

中国国家自然科学基金;

关键词：

TUMOR-ASSOCIATED MACROPHAGES; MICROGLIA/MACROPHAGE POLARIZATION DYNAMICS; GENE-EXPRESSION PROFILES; ADOPTIVE CELL TRANSFER; FC-GAMMA RECEPTORS; DENDRITIC CELL; MYELOID CELLS; PERIVASCULAR MACROPHAGES; ALTERNATIVE ACTIVATION; INFLAMMATORY MONOCYTES;

D O I：

10.1038/s41392-021-00506-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Immunotherapy is regarded as the most promising treatment for cancers. Various cancer immunotherapies, including adoptive cellular immunotherapy, tumor vaccines, antibodies, immune checkpoint inhibitors, and small-molecule inhibitors, have achieved certain successes. In this review, we summarize the role of macrophages in current immunotherapies and the advantages of targeting macrophages. To better understand and make better use of this type of cell, their development and differentiation characteristics, categories, typical markers, and functions were collated at the beginning of the review. Therapeutic strategies based on or combined with macrophages have the potential to improve the treatment efficacy of cancer therapies.

引用

页数：21

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