Mesenchymal stem cell

被引：16

作者：

Monteiro, Betania Souza ^{[1
]}

Argolo Neto, Napoleao Martins ^{[2
]}

Del Carlo, Ricardo Junqueira ^{[3
]}

机构：

[1] Univ Fed Vicosa, Programa Posgrad Med Vet, BR-36570000 Vicosa, MG, Brazil

[2] Univ Fed Espirito Santo, Dept Vet, Alegre, ES, Brazil

[3] Univ Fed Vicosa, Dept Vet, BR-36570000 Vicosa, MG, Brazil

来源：

CIENCIA RURAL | 2010年 / 40卷 / 01期

关键词：

cell therapy; immunological properties; growth factors; cytokines; tissue repair; MARROW STROMAL CELLS; HUMAN BONE-MARROW; BIOLOGY; TRANSPLANTATION; OSTEOTOMY; PERICYTES; THERAPY; TISSUES; NICHE; MSCS;

D O I：

10.1590/S0103-84782010000100040

中图分类号：

S3 [农学（农艺学）];

学科分类号：

0901 ;

摘要：

Of all the stem cells studied so far, the mesenchymal stem cells (MSC) stand out for their high plasticity and capacity of generating mesodermal and non-mesodermal tissues. In addition, immunomodulatory and immunosuppressive features that expand possibilities for therapeutic use are present in these cells. A variety of pro and anti-inflammatory cytokines and growth factors are secrete for MSC and provide a modulation of inflammatory response, re-establishment of vascular supply and adequate repair of the tissue, contributing to tissue homeostasis under physiologic conditions. Therefore, they can induce secretion of soluble factors that stimulate their differentiation by other cells present at the niche's tissue, promoting the repair process. Cell therapy using MSC is a promises therapeutic alternative, but understanding the biology of these cells is still under construction. The aim of the article is to conduct a short review of these undifferentiated mesenchymal cells.

引用

页码：238 / 245

页数：8

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