Synthetic strategies toward the synthesis of enoxacin-, levofloxacin-, and gatifloxacin-based compounds: A review

被引：32

作者：

Zahoor, Ameer Fawad ^{[1
]}

Yousaf, Muhammad ^{[1
]}

Siddique, Rabia ^{[1
]}

Ahmad, Sajjad ^{[2
]}

Naqvi, Syed Ali Raza ^{[1
]}

Rizvi, Sayyad Muhammad Ali ^{[3
]}

机构：

[1] Govt Coll Univ Faisalabad, Inst Chem, Faisalabad 38000, Pakistan

[2] Univ Engn & Technol Lahore, Dept Chem, Faisalabad Campus, Faisalabad, Pakistan

[3] Govt Coll Univ, Dept Chem, Lahore, Pakistan

来源：

SYNTHETIC COMMUNICATIONS | 2017年 / 47卷 / 11期

关键词：

Antibacterial activity; enoxacin; fluoroquinolones; gatifloxacin; levofloxacin; VITRO ANTIBACTERIAL ACTIVITY; ANTIMYCOBACTERIAL ACTIVITIES; DERIVATIVES; QUINOLONES; FLUOROQUINOLONES; CIPROFLOXACIN; PENETRATION; INFECTIONS; INHIBITION; BACTERIA;

D O I：

10.1080/00397911.2017.1300921

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Enoxacin, levofloxacin, and gatifloxacin represent one of the most important prerogative scaffolds in drug development. They possess broad spectrum antimicrobial and anti-inflammatory activities. They inhibit bacterial growth by blocking their topoisomerase enzyme which is necessary for the proper functioning of bacterial DNA. In this article, we have reviewed the synthetic approaches involved in the synthesis of derivatives of enoxacin, levofloxacin, and gatifloxacin.

引用

页码：1021 / 1039

页数：19

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