Small Gold Nanoparticles Synthesized with Sodium Citrate and Heavy Water: Insights into the Reaction Mechanism

被引：210
作者：
Ojea-Jimenez, Isaac [1 ,2 ]
Romero, Francisco M. [3 ]
Bastus, Neus G.
Puntes, Victor [4 ]
机构：
[1] CSIC, ICN, CIN2, Bellaterra 08193, Spain
[2] Endor Nanotechnol SL, Barcelona 08028, Spain
[3] Univ Valencia, Inst Ciencia Mol, E-46980 Paterna, Spain
[4] ICREA, Barcelona 08093, Spain
来源：
JOURNAL OF PHYSICAL CHEMISTRY C | 2010年 / 114卷 / 04期
关键词：
PARTICLE-SIZE; OXIDATION; SEPARATION; PEPTIDES; KINETICS; CLUSTER; GROWTH; ION; NM;
D O I：
10.1021/jp9091305
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The effect of solvent isotopic replacement (H for D) on the size of gold nanoparticles (Au NPs) prepared by sodium citrate reduction has been investigated. With increasing replacement of water by deuterium oxide, smaller sizes of Au NPs are obtained, which is interpreted as a consequence of a faster reduction. A mechanism in which a substitution complex, [AuCl3(C6H5O7)(-2)](-), is formed from AuCl4 and citrate ions prior to its rate-limiting disproportionation into products is suggested. This novel procedure offers an attractive alternative to the existing ones and opens a full range of possibilities for biological studies.
引用
收藏
页码：1800 / 1804
页数：5
相关论文
共 40 条
[1]   The molecular architecture of the nuclear pore complex [J].
Alber, Frank ;
Dokudovskaya, Svetlana ;
Veenhoff, Liesbeth M. ;
Zhang, Wenzhu ;
Kipper, Julia ;
Devos, Damien ;
Suprapto, Adisetyantari ;
Karni-Schmidt, Orit ;
Williams, Rosemary ;
Chait, Brian T. ;
Sali, Andrej ;
Rout, Michael P. .
NATURE, 2007, 450 (7170) :695-701
[2]   Less is more in medicine - Sophisticated forms of nanotechnology will find some of their first real-world applications in biomedical research, disease diagnosis and, possibly, therapy [J].
Alivisatos, AP .
SCIENTIFIC AMERICAN, 2001, 285 (03) :66-73
[3]   Homogeneous Conjugation of Peptides onto Gold Nanoparticles Enhances Macrophage Response [J].
Bastus, Neus G. ;
Sanchez-Tillo, Ester ;
Pujals, Silvia ;
Farrera, Consol ;
Lopez, Carmen ;
Giralt, Ernest ;
Celada, Antonio ;
Lloberas, Jorge ;
Puntes, Victor .
ACS NANO, 2009, 3 (06) :1335-1344
[4]   Peptides conjugated to gold nanoparticles induce macrophage activation [J].
Bastus, Neus G. ;
Sanchez-Tillo, Ester ;
Pujals, Silvia ;
Farrera, Consol ;
Kogan, Marcelo J. ;
Giralt, Ernest ;
Celada, Antonio ;
Lloberas, Jorge ;
Puntes, Victor .
MOLECULAR IMMUNOLOGY, 2009, 46 (04) :743-748
[5]   SYNTHESIS OF THIOL-DERIVATIZED GOLD NANOPARTICLES IN A 2-PHASE LIQUID-LIQUID SYSTEM [J].
BRUST, M ;
WALKER, M ;
BETHELL, D ;
SCHIFFRIN, DJ ;
WHYMAN, R .
JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1994, (07) :801-802
[6]   Gold nanoparticles are taken up by human cells but do not cause acute cytotoxicity [J].
Connor, EE ;
Mwamuka, J ;
Gole, A ;
Murphy, CJ ;
Wyatt, MD .
SMALL, 2005, 1 (03) :325-327
[7]  
COOPER GM, 2008, CELL MOL APPROACH, P361
[8]   Gold nanoparticles: Assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology [J].
Daniel, MC ;
Astruc, D .
CHEMICAL REVIEWS, 2004, 104 (01) :293-346
[9]   Surface plasmon resonance scattering and absorption of anti-EGFR antibody conjugated gold nanoparticles in cancer diagnostics: Applications in oral cancer [J].
El-Sayed, IH ;
Huang, XH ;
El-Sayed, MA .
NANO LETTERS, 2005, 5 (05) :829-834
[10]   CONTROLLED NUCLEATION FOR REGULATION OF PARTICLE-SIZE IN MONODISPERSE GOLD SUSPENSIONS [J].
FRENS, G .
NATURE-PHYSICAL SCIENCE, 1973, 241 (105) :20-22
1234