Nanomaterial-Assisted Signal Enhancement of Hybridization for DNA Biosensors: A Review

被引：35

作者：

Liu, Jinhuai ^{[1
]}

Liu, Jinyun ^{[1
]}

Yang, Liangbao ^{[1
]}

Chen, Xing ^{[1
]}

Zhang, Meiyun ^{[1
]}

Meng, Fanli ^{[1
]}

Luo, Tao ^{[1
]}

Li, Minqiang ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Intelligent Machines, Key Lab Biomimet Sensing & Adv Robot Technol, Hefei 230031, Peoples R China

来源：

SENSORS | 2009年 / 9卷 / 09期

基金：

中国国家自然科学基金; 国家高技术研究发展计划(863计划);

关键词：

DNA detection; sensitivity; nanosemiconductors; quantum-dots; nanopaticles; carbon nanotubes; QUANTUM DOTS; GOLD NANOPARTICLES; SILVER NANOPARTICLES; SENSITIVE DETECTION; SEQUENCE DETECTION; FRET; FLUORESCENCE; FILM; IMMOBILIZATION; AMPLIFICATION;

D O I：

10.3390/s90907343

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Detection of DNA sequences has received broad attention due to its potential applications in a variety of fields. As sensitivity of DNA biosensors is determined by signal variation of hybridization events, the signal enhancement is of great significance for improving the sensitivity in DNA detection, which still remains a great challenge. Nanomaterials, which possess some unique chemical and physical properties caused by nanoscale effects, provide a new opportunity for developing novel nanomaterial-based signal-enhancers for DNA biosensors. In this review, recent progress concerning this field, including some newly-developed signal enhancement approaches using quantum-dots, carbon nanotubes and their composites reported by our group and other researchers are comprehensively summarized. Reports on signal enhancement of DNA biosensors by non-nanomaterials, such as enzymes and polymer reagents, are also reviewed for comparison. Furthermore, the prospects for developing DNA biosensors using nanomaterials as signal-enhancers in future are also indicated.

引用

页码：7343 / 7364

页数：22

共 110 条

[1] Disasters drive DNA forensics to reunite families [J].