Non-invasive determination of concentration of compounds in strongly absorbing biological tissue

被引：4

作者：

Bolt, RA ^{[1
]}

Kanger, JS ^{[1
]}

de Mul, FFM ^{[1
]}

Wu, XM ^{[1
]}

Yeh, SJ ^{[1
]}

Khalil, OS ^{[1
]}

机构：

[1] Univ Twente, Dept Appl Phys, Bio Phys Tech Grp, NL-7500 AE Enschede, Netherlands

来源：

OPTICAL BIOPSY III | 2000年 / 3917卷

关键词：

tissue optics; light scattering; in vivo measurement; haemoglobin; analytes; non-invasive; optical parameters;

D O I：

10.1117/12.382729

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We describe a non-invasive method for the determination of optical parameters of highly scattering media, such as biological tissue. An advantage of this method is that it does not rely on diffusion theory, thus it is applicable to strongly absorbing media and at small source-detector separations. Monte Carlo simulations and phantom measurements are used to illustrate the achievable accuracy of the system. The method was applied to non-invasive in-vivo tracking of haemoglobin concentration in biological tissue. The results correlated well to clinically (invasively) determined Hb concentrations.

引用

页码：168 / 175

页数：8

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