The NIH Human Microbiome Project

被引：1390

作者：

Peterson, Jane ^{[1
]}

Garges, Susan ^{[2
]}

Giovanni, Maria

McInnes, Pamela ^{[1
,3
]}

Wang, Lu ^{[1
]}

Schloss, Jeffery A. ^{[1
]}

Bonazzi, Vivien ^{[1
]}

McEwen, Jean E. ^{[1
]}

Wetterstrand, Kris A.

Deal, Carolyn ^{[2
]}

Baker, Carl C. ^{[4
]}

Di Francesco, Valentina ^{[2
]}

Howcroft, T. Kevin ^{[5
]}

Karp, Robert W. ^{[6
]}

Lunsford, R. Dwayne ^{[3
]}

Wellington, Christopher R. ^{[1
]}

Belachew, Tsegahiwot ^{[1
]}

Wright, Michael ^{[2
]}

Giblin, Christina ^{[2
]}

David, Hagit ^{[2
]}

Mills, Melody ^{[2
]}

Salomon, Rachelle ^{[2
]}

Mullins, Christopher ^{[6
]}

Akolkar, Beena ^{[6
]}

Begg, Lisa ^{[7
]}

Davis, Cindy ^{[5
]}

Grandison, Lindsey ^{[8
]}

Humble, Michael ^{[9
]}

Khalsa, Jag ^{[10
]}

Little, A. Roger ^{[11
]}

Peavy, Hannah ^{[12
]}

Pontzer, Carol ^{[13
]}

Portnoy, Matthew ^{[14
]}

Sayre, Michael H. ^{[15
]}

Starke-Reed, Pamela

Zakhari, Samir ^{[8
]}

Read, Jennifer ^{[3
,16
]}

Watson, Bracie ^{[17
]}

Guyer, Mark ^{[1
]}

机构：

[1] NHGRI, NIH, Bethesda, MD 20892 USA

[2] NIAID, NIH, Bethesda, MD 20892 USA

[3] Natl Inst Dent & Craniofacial Res, NIH, Bethesda, MD 20892 USA

[4] NIAMSD, NIH, Bethesda, MD 20892 USA

[5] NCI, NIH, Bethesda, MD 20892 USA

[6] NIDDKD, NIH, Bethesda, MD 20892 USA

[7] NIH, Off Director, Bethesda, MD 20892 USA

[8] NIAAA, NIH, Bethesda, MD 20892 USA

[9] NIEHS, NIH, Bethesda, MD 20892 USA

[10] NIDA, NIH, Bethesda, MD 20892 USA

[11] NIMH, NIH, Bethesda, MD 20892 USA

[12] NHLBI, NIH, Bethesda, MD 20892 USA

[13] NIH, Natl Ctr Complementary & Alternat Med, Bethesda, MD 20892 USA

[14] NIGMS, NIH, Bethesda, MD 20892 USA

[15] NIH, Natl Ctr Res Resources, Bethesda, MD 20892 USA

[16] NICHHD, NIH, Bethesda, MD 20892 USA

[17] Natl Inst Deafness & Other Commun Disorders, NIH, Bethesda, MD 20892 USA

来源：

GENOME RESEARCH | 2009年 / 19卷 / 12期

关键词：

MOLECULAR ANALYSIS; METAGENOMICS; DIVERSITY; COMMUNITY; SEQUENCE; CLONING;

D O I：

10.1101/gr.096651.109

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Human Microbiome Project (HMP), funded as an initiative of the NIH Roadmap for Biomedical Research (http://nihroadmap.nih.gov), is a multi-component community resource. The goals of the HMP are: ( 1) to take advantage of new, high-throughput technologies to characterize the human microbiome more fully by studying samples from multiple body sites from each of at least 250 "normal'' volunteers; ( 2) to determine whether there are associations between changes in the microbiome and health/disease by studying several different medical conditions; and ( 3) to provide both a standardized data resource and new technological approaches to enable such studies to be undertaken broadly in the scientific community. The ethical, legal, and social implications of such research are being systematically studied as well. The ultimate objective of the HMP is to demonstrate that there are opportunities to improve human health through monitoring or manipulation of the human microbiome. The history and implementation of this new program are described here.

引用

页码：2317 / 2323

页数：7

共 30 条

[1] Defining the normal bacterial flora of the oral cavity [J].