Self and directed assembly: people and molecules

被引:8
|
作者
James, Tony D. [1 ]
机构
[1] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England
来源
基金
英国工程与自然科学研究理事会; 日本学术振兴会;
关键词
boronic acids; fluorescence; glucose sensor; self and directed assembly; supramolecular; BIOMIMETIC ION-TRANSPORT; CHIRAL DERIVATIZATION PROTOCOLS; MODULAR FLUORESCENCE SENSORS; BORONIC ACID RECEPTORS; NMR ANALYSIS; ENANTIOMERIC PURITY; IN-VIVO; ENANTIOSELECTIVE RECOGNITION; SPECTROSCOPIC ANALYSIS; BISBORONIC ACID;
D O I
10.3762/bjoc.12.42
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Self-assembly and directed-assembly are two very important aspects of supramolecular chemistry. As a young postgraduate student working in Canada with Tom Fyles my introduction to Supramolecular Chemistry was through the self-assembly of phospholipid membranes to form vesicles for which we were developing unimolecular and self-assembling transporter molecules. The next stage of my development as a scientist was in Japan with Seiji Shinkai where in a "Eureka" moment, the boronic acid templating unit (directed-assembly) of Wulff was combined with photoinduced electron transfer systems pioneered by De Silva. The result was a turn-on fluorescence sensor for saccharides; this simple result has continued to fuel my research to the present day. Throughout my career as well as assembling molecules, I have enjoyed bringing together researchers in order to develop collaborative networks. This is where molecules meet people resulting in assemblies worth more than the individual "molecule" or "researcher". My role in developing networks with Japan was rewarded by the award of a Daiwa-Adrian Prize in 2013 and I was recently rewarded for developing networks with China with an Inaugural CASE Prize in 2015.
引用
收藏
页码:391 / 405
页数:15
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