Systemic tissue inhibitor of metalloproteinase-1 gene delivery reduces neointimal hyperplasia in balloon-injured rat carotid artery

被引：43
作者：
Furman, C
Luo, Z
Walsh, K
Duverger, N
Copin, C
Fruchart, JC
Rouis, M
机构：
[1] Inst Pasteur, F-59019 Lille, France
[2] INSERM, U 545, F-59019 Lille, France
[3] St Elizabeths Med Ctr, Div Cardiovasc Res, Boston, MA 02135 USA
[4] Boston Univ, Boston, MA 02118 USA
[5] Aventis Pharma, Dept Cardiol, F-94403 Vitry Sur Seine, France
来源：
FEBS LETTERS | 2002年 / 531卷 / 02期
关键词：
matrix metalloproteinase; tissue inhibitor of metalloprotemase; restenosis; gene therapy;
D O I：
10.1016/S0014-5793(02)03388-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Metalloproteinases (MMP)-2 and MMP-9 play a role in smooth muscle cell (SMC) migration from the media to the intima following arterial injury. Intravenous administration of adenovirus encoding tissue inhibitor of metalloproteinase-1 (TIMP-1) into balloon-injured rat arteries (3 X 10(11) viral particles/rat; n = 7) resulted in a transient expression of TIMP-1 and a significant inhibition of neointima thickening within 16 days (similar to40% vs. control; P = 0.012). Three days after injury, the number of intimal SMCs was decreased by similar to98% in TIMP-l-treated rats. However, no alteration was seen in intimal SMC proliferation after 13 days of injury. Therefore, our results show that systemic gene transfer of TIMP-1 is a promising approach in early restenosis treatment. (C) 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
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收藏
页码：122 / 126
页数：5
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