Polyphenol intake is associated with low-grade inflammation, using a novel data analysis from the Moli-sani study

被引：90

作者：

Pounis, George ^{[1
]}

Bonaccio, Marialaura ^{[1
]}

Di Castelnuovo, Augusto ^{[1
]}

Costanzo, Simona ^{[1
]}

De Curtis, Amalia ^{[1
]}

Persichillo, Mariarosaria ^{[1
]}

Sieri, Sabina ^{[2
]}

Donati, Maria Benedetta ^{[1
]}

Cerletti, Chiara ^{[1
]}

de Gaetano, Giovanni ^{[1
]}

Iacoviello, Licia ^{[1
]}

机构：

[1] IRCCS Ist Neurol Mediterraneo Neuromed, Dept Epidemiol & Prevent, Pozzilli, IS, Italy

[2] Fdn IRCCS Ist Nazl Tumori, Epidemiol & Prevent Unit, Milan, Italy

来源：

THROMBOSIS AND HAEMOSTASIS | 2016年 / 115卷 / 02期

基金：

欧盟第七框架计划;

关键词：

Cardiovascular disease; flavonoids; inflammation; lignans; polyphenols; C-REACTIVE PROTEIN; SYSTEMIC INFLAMMATION; MEDITERRANEAN DIET; OXIDATIVE STRESS; LYMPHOCYTE RATIO; CONSUMPTION; RISK; NEUTROPHIL; PREVENTION; BIOMARKERS;

D O I：

10.1160/TH15-06-0487

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The association of polyphenol content of human diet with low-grade inflammation is not yet fully understood. It was the objective of this study to evaluate the association of flavonoid and lignan intake with frequently used and easily applicable in clinical practice low-grade inflammation biomarkers, in a novel holistic approach. A total of 5,948 women and 5,965 men ( aged >= 35years) were analysed from the Moli-sani cohort, randomly recruited from the general population. The EPIC-FFQ was used for dietary assessment. Flavonol, flavone, flavanone, flavanol, anthocyanin, isoflavone and lignan intakes were calculated using Eurofir eBASIS and the polyphenol antioxidant content (PAC)-score was constructed to assess the total content of diet in these nutrients. CRP levels, WBC and PLT count and granulocyte to lymphocyte ratio were conceived as low-grade inflammation biomarkers. INFLA-score was constructed summarizing synergistic effects of these biomarkers. The INFLA-score was negatively associated with PAC-score in different levels of adjustment, in both genders (for all beta-coef<0, P<0.05). 10 units increase in PAC-score was associated with 5-8 % decrease in the likelihood of higher low-grade inflammation status (i.e. higher quartile of INFLA-score) in men and women (odds ratio [ORs] 0.92 to 0.95, p<0.05). The total variation of INFLA-score that was explained by PAC-score was estimated to be 16.7 % in women and 9.1 % in men (% R-2=16.7 and 9.1). In conclusion, polyphenol content of diet evaluated in a holistic approach was negatively associated with a score of low-grade inflammation biomarkers in a large population based study. For the first time low-grade inflammation was evaluated in a holistic way through INFLA-score and was associated with polyphenol content of diet.

引用

页码：344 / 352

页数：9