New Developments in Microbiome in Alcohol-Associated and Nonalcoholic Fatty Liver Disease

被引：12

作者：

Hartmann, Phillipp ^{[1
,2
]}

Schnabl, Bernd ^{[2
,3
]}

机构：

[1] Univ Calif San Diego, Dept Pediat, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Dept Med, Biomed Res Facil 2 BRF2,Room 4A22,9500 Gilman Dr, La Jolla, CA 92093 USA

[3] VA San Diego Healthcare Syst, Dept Med, San Diego, CA USA

来源：

SEMINARS IN LIVER DISEASE | 2021年 / 41卷 / 01期

基金：

美国国家卫生研究院;

关键词：

microbiome; alcohol-associated liver disease; nonalcoholic fatty liver disease; new developments; precision medicine; INTESTINAL BACTERIAL OVERGROWTH; GUT MICROBIOTA; PROBIOTIC VSLNUMBER-3; INSULIN SENSITIVITY; HEPATIC-INJURY; CHOLINE INTAKE; DOUBLE-BLIND; CIRRHOSIS; ETHANOL; STEATOHEPATITIS;

D O I：

10.1055/s-0040-1719174

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Alcohol-associated liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD) are important causes of morbidity and mortality worldwide. The intestinal microbiota is involved in the development and progression of both ALD and NAFLD. Here we describe associated changes in the intestinal microbiota, and we detail randomized clinical trials in ALD and NAFLD which evaluate treatments modulating the intestinal microbiome including fecal microbiota transplantation, probiotics, prebiotics, synbiotics, and antibiotics. Finally, we discuss precision medicine approaches targeting the intestinal microbiome to ameliorate ALD and NAFLD.

引用

页码：87 / 102

页数：16

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