Promoting bone regeneration by 3D-printed poly(glycolic acid)/hydroxyapatite composite scaffolds

被引：28

作者：

Yeo, Taegyun ^{[1
]}

Ko, Young-Gwang ^{[1
]}

Kim, Eun Jin ^{[2
]}

Kwon, Oh Kyoung ^{[3
]}

Chung, Ho Yun ^{[4
]}

Kwon, Oh Hyeong ^{[1
]}

机构：

[1] Kumoh Natl Inst Technol, Dept Polymer Sci & Engn, Gumi 39177, Gyeongbuk, South Korea

[2] Therac Biomed Co Ltd, Seongnam 13201, Gyeonggi, South Korea

[3] Kyungpook Natl Univ, Gastr Canc Ctr, Chilgok Hosp, Daegu 41404, South Korea

[4] Kyungpook Natl Univ, Sch Med, Dept Plast & Reconstruct Surg, CMRI, Daegu 41944, South Korea

来源：

JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY | 2021年 / 94卷

基金：

新加坡国家研究基金会;

关键词：

Hydroxyapatite; Poly(glycolic acid); 3D printing; Scaffold; Tissue engineering;

D O I：

10.1016/j.jiec.2020.11.004

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Hydroxyapatite (HAp) is a major bone graft component for hard tissue regeneration. However, sintered HAp has poor formability and mechanical properties. Porous 3D scaffolds for bone tissue regeneration were printed with computer-aided modeling using poly(glycolic acid) (PGA) and HAp. PGA scaffolds containing HAp nanoparticles were fabricated with a 400 mu m pore size. PGA/HAp scaffolds containing 12.5 wt% HAp showed considerable compressive strength, osteogenesis, mineralization, and biodegradation. In in vivo animal experiments, the PGA/HAp group exhibited 47% bone regeneration, with superior bone mineral density 8 weeks after surgery. 3D-printed PGA/HAp scaffolds could provide a feasible option to promote patient-specific bone regeneration. (C) 2020 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.

引用

页码：343 / 351

页数：9

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