Inhibition of TGF-β1 promotes functional recovery after spinal cord injury

被引：64

作者：

Kohta, Masaaki ^{[1
,2
]}

Kohmura, Eiji ^{[2
]}

Yamashita, Toshihide ^{[1
]}

机构：

[1] Osaka Univ, Dept Mol Neurosci, Grad Sch Med, Osaka 5650871, Japan

[2] Kobe Univ, Dept Neurosurg, Grad Sch Med, Kobe, Hyogo, Japan

来源：

NEUROSCIENCE RESEARCH | 2009年 / 65卷 / 04期

关键词：

TGF-beta; 1; Spinal cord injury; Corticospinal tract; Axon; Motor function; CENTRAL-NERVOUS-SYSTEM; GROWTH-FACTOR-BETA; AXON REGENERATION; TRANSFORMING GROWTH-FACTOR-BETA-1; GLIAL INHIBITION; SCAR TISSUE; ADULT RATS; PROTEIN; CNS; EXPRESSION;

D O I：

10.1016/j.neures.2009.08.017

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Trauma to the spinal cord initiates a series of cellular and biochemical processes that damage both neurons and glia. TGF-beta and its receptors are expressed around the injury site following a spinal cord injury. Here, we report that the intrathecal administration of a neutralizing antibody to TGF-beta 1 in rats with thoracic spinal cord contusion results in a significant enhancement of the locomotor recovery. The inhibition of TGF-beta 1 suppresses glial scar formation and upregulates microglia/macrophage activation after the injury, presumably providing a favorable environment for restoration of the neural network. Rats treated with the anti-TGF-beta 1 antibody exhibited a mild enhancement of growth and/or preservation of axons in the injured spinal cord caudal to the site of contusion. These results support the possibility of using TGF-beta 1 inhibitors in the treatment of human spinal cord injuries. (C) 2009 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.

引用

页码：393 / 401

页数：9

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