Applications of Immunogenomics to Cancer

被引：170

作者：

Liu, X. Shirley ^{[1
]}

Mardis, Elaine R. ^{[2
,3
]}

机构：

[1] Harvard TH Chan Sch Publ Hlth, Dana Farber Canc Inst, Dept Biostat & Computat Biol, 450 Brookline Ave, Boston, MA 02215 USA

[2] Nationwide Childrens Hosp, Inst Genom Med, 575 Childrens Crossrd, Columbus, OH 43205 USA

[3] Ohio State Univ, Coll Med, 575 Childrens Crossrd, Columbus, OH 43205 USA

来源：

CELL | 2017年 / 168卷 / 04期

基金：

美国国家卫生研究院;

关键词：

T-CELL REPERTOIRE; IDENTIFYING FUSION TRANSCRIPTS; B-CELLS; PD-1; BLOCKADE; TUMOR PURITY; CHIMERIC RECEPTORS; HYBRID SELECTION; IMMUNE-RESPONSES; CTLA-4; SEQUENCING DATA;

D O I：

10.1016/j.cell.2017.01.014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cancer immunogenomics originally was framed by research supporting the hypothesis that cancer mutations generated novel peptides seen as "non-self'' by the immune system. The search for these "neoantigens'' has been facilitated by the combination of new sequencing technologies, specialized computational analyses, and HLA binding predictions that evaluate somatic alterations in a cancer genome and interpret their ability to produce an immune-stimulatory peptide. The resulting information can characterize a tumor's neoantigen load, its cadre of infiltrating immune cell types, the T or B cell receptor repertoire, and direct the design of a personalized therapeutic.

引用

页码：600 / 612

页数：13

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