Tuning the solubility of ionophores: glutathione-mediated transport of chloride ions across hydrophobic membranes

被引：40

作者：

Akhtar, Nasim ^{[1
]}

Pradhan, Nirmalya ^{[1
]}

Saha, Abhishek ^{[1
]}

Kumar, Vishnu ^{[2
]}

Biswas, Oindrila ^{[1
]}

Dey, Subhasis ^{[1
]}

Shah, Manisha ^{[2
]}

Kumar, Sachin ^{[2
]}

Manna, Debasis ^{[1
]}

机构：

[1] Indian Inst Technol Guwahati, Dept Chem, Gauhati 781039, Assam, India

[2] Indian Inst Technol Guwahati, Dept Biosci & Bioengn, Gauhati 781039, Assam, India

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 58期

关键词：

APOPTOSIS; DELIVERY; CHEMISTRY; CHANNELS;

D O I：

10.1039/c9cc04518j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A stimuli-responsive anion transport strategy was successfully employed to regulate the water solubility of ionophores and promote controlled transport of Cl- ions across lipid bilayers. A sulfonium-based proanionophore was efficiently activated by glutathione to regenerate the active anionophore, which allowed controlled transport of Cl- ions in a cellular environment with lower cytotoxicity.

引用

页码：8482 / 8485

页数：4

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