Role and Regulation of Pif1 Family Helicases at the Replication Fork

被引：8
|
作者：
Malone, Emory G. [1 ]
Thompson, Matthew D. [1 ]
Byrd, Alicia K. [1 ,2 ]
机构：
[1] Univ Arkansas Med Sci, Dept Biochem & Mol Biol, Little Rock, AR 72205 USA
[2] Univ Arkansas Med Sci, Winthrop P Rockefeller Canc Inst, Little Rock, AR 72205 USA
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 07期
关键词：
Pif1; helicase; DNA helicase; replication fork; replication fork barriers; G-quadruplexes; telomerase; BREAK-INDUCED REPLICATION; DNA HELICASE; G-QUADRUPLEX; RIBOSOMAL DNA; FISSION YEAST; SCHIZOSACCHAROMYCES-POMBE; GENOME INSTABILITY; SHORT TELOMERES; OKAZAKI FRAGMENTS; 3'-DNA HELICASE;
D O I：
10.3390/ijms23073736
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Pif1 helicases are a multifunctional family of DNA helicases that are important for many aspects of genomic stability in the nucleus and mitochondria. Pif1 helicases are conserved from bacteria to humans. Pif1 helicases play multiple roles at the replication fork, including promoting replication through many barriers such as G-quadruplex DNA, the rDNA replication fork barrier, tRNA genes, and R-loops. Pif1 helicases also regulate telomerase and promote replication termination, Okazaki fragment maturation, and break-induced replication. This review highlights many of the roles and regulations of Pif1 at the replication fork that promote cellular health and viability.
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页数：20
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