Moving smaller in drug discovery and delivery

被引：214
作者：
LaVan, DA
Lynn, DM
Langer, R [1 ]
机构：
[1] MIT, Dept Chem Engn, Cambridge, MA 02139 USA
[2] MIT, Div Hlth Sci, Cambridge, MA 02139 USA
[3] Childrens Hosp, Boston, MA 02115 USA
来源：
NATURE REVIEWS DRUG DISCOVERY | 2002年 / 1卷 / 01期
关键词：
D O I：
10.1038/nrd707
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Advances in new micro- and nanotechnologies are accelerating the identification and evaluation of drug candidates, and the development of new delivery technologies that are required to transform biological potential into medical reality. This article will highlight the emerging micro- and nanotechnology tools, techniques and devices that are being applied to advance the fields of drug discovery and drug delivery. Many of the promising applications of micro- and nanotechnology are likely to occur at the interfaces between microtechnology, nanotechnology and biochemistry.
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收藏
页码：77 / 84
页数：8
相关论文
共 97 条
[31]   Sequence-specific detection of individual DNA strands using engineered nanopores [J].
Howorka, S ;
Cheley, S ;
Bayley, H .
NATURE BIOTECHNOLOGY, 2001, 19 (07) :636-639
[32]   Pushing the limits of lithography [J].
Ito, T ;
Okazaki, S .
NATURE, 2000, 406 (6799) :1027-1031
[33]  
JAIN RA, 1999, RELEASE BIOACT MAT, V26, P883
[34]   Characterization of individual polynucleotide molecules using a membrane channel [J].
Kasianowicz, JJ ;
Brandin, E ;
Branton, D ;
Deamer, DW .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (24) :13770-13773
[35]   Lack of pain associated with microfabricated microneedles [J].
Kaushik, S ;
Hord, AH ;
Denson, DD ;
McAllister, DV ;
Smitra, S ;
Allen, MG ;
Prausnitz, MR .
ANESTHESIA AND ANALGESIA, 2001, 92 (02) :502-504
[36]   Tissue microarrays for high-throughput molecular profiling of tumor specimens [J].
Kononen, J ;
Bubendorf, L ;
Kallioniemi, A ;
Bärlund, M ;
Schraml, P ;
Leighton, S ;
Torhorst, J ;
Mihatsch, MJ ;
Sauter, G ;
Kallioniemi, OP .
NATURE MEDICINE, 1998, 4 (07) :844-847
[37]   Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells [J].
Lewin, M ;
Carlesso, N ;
Tung, CH ;
Tang, XW ;
Cory, D ;
Scadden, DT ;
Weissleder, R .
NATURE BIOTECHNOLOGY, 2000, 18 (04) :410-414
[38]   PARTICLE-SIZE REDUCTION FOR IMPROVEMENT OF ORAL BIOAVAILABILITY OF HYDROPHOBIC DRUGS .1. ABSOLUTE ORAL BIOAVAILABILITY OF NANOCRYSTALLINE DANAZOL IN BEAGLE DOGS [J].
LIVERSIDGE, GG ;
CUNDY, KC .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1995, 125 (01) :91-97
[39]   Synthetic DNA delivery systems [J].
Luo, D ;
Saltzman, WM .
NATURE BIOTECHNOLOGY, 2000, 18 (01) :33-37
[40]   Printing small molecules as microarrays and detecting protein-ligand interactions en masse [J].
MacBeath, G ;
Koehler, AN ;
Schreiber, SL .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (34) :7967-7968
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