Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon

被引：322
作者：
Cervantes-Barragan, Luisa
Zuest, Roland
Weber, Friedernann
Spiegel, Martin
Lang, Karl S.
Akira, Shizuo
Thiel, Volker [1 ]
Ludewig, Burkhard
机构：
[1] Kantonsspital, Res Dept, CH-9007 St Gallen, Switzerland
[2] Hosp Especialidades Ctr Med La Raza, Unidad Invest Med Inmunoquim, Mexico City, DF, Mexico
[3] Univ Freiburg, Inst Med Microbiol & Hyg, Abt Virol, D-7800 Freiburg, Germany
[4] Univ Zurich Hosp, Inst Expt Immunol, CH-8091 Zurich, Switzerland
[5] Osaka Univ, Dept Host Def, Suita, Osaka 565, Japan
来源：
BLOOD | 2007年 / 109卷 / 03期
关键词：
D O I：
10.1182/blood-2006-05-023770
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
This study demonstrates a unique and crucial role of plasmacytold dendritic cells (pDCs) and pDC-derived type I interferons (IFNs) in the pathogenesis of mouse coronavirus infection. pDCs controlled the fast replicating mouse hepatitis virus (MHV) through the immediate production of type I IFNs. Recognition of MHV by pDCs was mediated via TLR7 ensuring a swift IFN-alpha production following encounter with this cytopathic RNA virus. Furthermore, the particular type I IFN response pattern was not restricted to the murine coronavirus, but was also found in infection with the highly cytopathic human severe acute respiratory syndrome (SARS) coronavirus. Taken together, our results suggest that rapid production of type I IFNs by pDCs is essential for the control of potentially lethal coronavirus infections.
引用
收藏
页码：1131 / 1137
页数：7
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