Epigenetic Dysregulation in Cancer

被引：58
|
作者：
Muntean, Andrew G. [1 ]
Hess, Jay L. [1 ]
机构：
[1] Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA
来源：
AMERICAN JOURNAL OF PATHOLOGY | 2009年 / 175卷 / 04期
关键词：
POLYCOMB-GROUP GENE; GROUP PROTEIN EZH2; HISTONE H3; DNA METHYLATION; PHD FINGER; METHYLTRANSFERASE ACTIVITY; MYELODYSPLASTIC SYNDROME; THERAPEUTIC TARGET; GENOMIC STRUCTURE; CHROMATIN;
D O I：
10.2353/ajpath.2009.081142
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
One of the great paradoxes in cellular differentiation is how cells with identical DNA sequences differentiate into so many different cell types. The mechanisms underlying this process involve epigenetic regulation mediated by alterations in DNA methylation, histone posttranslational modifications, and nucleosome remodeling. It is becoming increasingly clear that disruption of the "epigenome" as a result of alterations in epigenetic regulators is a fundamental mechanism in cancer. This has major implications for the future of both molecular diagnostics as well as cancer chemotherapy. (Am J Pathol 1361; DOI: 10.2353/ajpath.2009.081142)
引用
收藏
页码：1353 / 1361
页数：9
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