Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor - Containing vesicle transport

被引：577

作者：

Setou, M ^{[1
]}

Nakagawa, T ^{[1
]}

Seog, DH ^{[1
]}

Hirokawa, N ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Med, Dept Cell Biol & Anat, Bunkyo Ku, Tokyo, Japan

来源：

SCIENCE | 2000年 / 288卷 / 5472期

关键词：

D O I：

10.1126/science.288.5472.1796

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Experiments with vesicles containing N-methyl-D-aspartate (NMDA) receptor 2B (NR2B subunit) show that they are transported along microtubules by KIF17, a neuron-specific molecular motor in neuronal dendrites. Selective transport is accomplished by direct interaction of the KIF17 tail with a PDZ domain of mLin-10 (Mintl1/X11), which is a constituent of a large protein complex including mLin-2 (CASK), mLin-7 (MALS/VeLis), and the NR2B subunit. This interaction, specific for a neurotransmitter receptor critically important for plasticity in the postsynaptic terminal, may be a regulatory point for synaptic plasticity and neuronal morphogenesis.

引用

页码：1796 / 1802

页数：7

共 31 条

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