Nickel-Catalyzed Reductive Dicarbofunctionalization of Alkenes

被引：292

作者：

Garcia-Dominguez, Andres ^{[1
]}

Li, Zhaodong ^{[1
]}

Nevado, Cristina ^{[1
]}

机构：

[1] Univ Zurich, Dept Chem, Winterthurerstr 190, CH-8057 Zurich, Switzerland

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2017年 / 139卷 / 20期

基金：

瑞士国家科学基金会; 欧洲研究理事会;

关键词：

REDOX-ACTIVE ESTERS; ARYL IODIDES; COUPLING REACTIONS; ALKYL BROMIDES; INTERMOLECULAR TRIFLUOROMETHYLARYLATION; TERMINAL ALKENES; BORONIC ACIDS; HALIDES; ELECTROPHILES; RADICALS;

D O I：

10.1021/jacs.7b03195

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An intermolecular, three-component reductive dicarbofunctionalization of alkenes is presented here. The combination of Ni catalysis with TDAE as final reductant enables the direct formation of Csp(3)-Csp(3) and Csp(3)-Csp(2) bonds across a variety of pi-systems using two different electrophiles that are sequentially activated with exquisite selectivity under mild reaction conditions.

引用

页码：6835 / 6838

页数：4

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