Potassium supplementation mitigates corticosteroid-induced neuropsychiatric effects in pediatric oncology patients

被引：3

作者：

Pariury, Holly ^{[1
]}

Willhoite, John ^{[1
]}

Michlitsch, Jennifer ^{[1
]}

Agrawal, Anurag ^{[1
]}

机构：

[1] UCSF Benioff Childrens Hosp Oakland, Oakland, CA USA

来源：

PEDIATRIC HEMATOLOGY AND ONCOLOGY | 2019年 / 36卷 / 07期

关键词：

Corticosteroids; mood disorders; potassium chloride; leukemia; pediatrics; ACUTE LYMPHOBLASTIC-LEUKEMIA; CHILDREN; DEXAMETHASONE; MOOD; RISK;

D O I：

10.1080/08880018.2019.1659463

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Corticosteroids play an essential role in the treatment of pediatric malignancies, but have many untoward side effects including behavioral and mood disturbances which can be quite burdensome to families. Potassium chloride has been used anecdotally to decrease these neuropsychiatric effects but this experience has not been studied systematically. We therefore retrospectively reviewed our experience utilizing KCl supplementation to reduce corticosteroid-induced neuropsychiatric effects among children with acute lymphoblastic leukemia. Thirteen of 16 patients (81%) had a objective benefit with KCl at a median dose of 0.5 mEq/kg/day, with no reported adverse effects. Further prospective study is required to confirm these data.

引用

页码：445 / 450

页数：6

共 21 条

[1] Dexamethasone versus prednisone and daily oral versus weekly intravenous mercaptopurine for patients with standard-risk acute lymphoblastic leukemia: a report from the Children's Cancer Group [J].

Bostrom, BC ;

Sensel, MR ;

Sather, HN ;

Gaynon, PS ;

La, MK ;

Johnston, K ;

Erdmann, GR ;

Gold, S ;

Heerema, NA ;

Hutchinson, RJ ;

Provisor, AJ ;

Trigg, ME .

BLOOD, 2003, 101 (10) :3809-3817

[2]

Corkins M, 2010, S P E N PEDIAT NUTR

[3] Psychiatric Adverse Effects of Pediatric Corticosteroid Use [J].

Drozdowicz, Linda B. ;

Bostwick, J. Michael .

MAYO CLINIC PROCEEDINGS, 2014, 89 (06) :817-834

[4] PRESENTATION OF THE STEROID PSYCHOSES [J].

HALL, RCW ;

POPKIN, MK ;

STICKNEY, SK ;

GARDNER, ER .

JOURNAL OF NERVOUS AND MENTAL DISEASE, 1979, 167 (04) :229-236

[5] Deletion of the background potassium channel TREK-1 results in a depression-resistant phenotype [J].

Heurteaux, Catherine ;

Lucas, Guillaume ;

Guy, Nicolas ;

El Yacoubi, Malika ;

Thummler, Susanne ;

Peng, Xiao-Dong ;

Noble, Florence ;

Blondeau, Nicolas ;

Widmann, Catherine ;

Borsotto, Marc ;

Gobbi, Gabriella ;

Vaugeois, Jean-Marie ;

Debonnel, Guy ;

Lazdunski, Michel .

NATURE NEUROSCIENCE, 2006, 9 (09) :1134-1141

[6] Steroid-induced alterations of mood and behavior in children during treatment for acute lymphoblastic leukemia [J].

Hochhauser, CJ ;

Lewis, M ;

Kamen, BA ;

Cole, PD .

SUPPORTIVE CARE IN CANCER, 2005, 13 (12) :967-974

[7]

Judy Jennifer Toolan, 2013, Frontiers in Genetics, V4, P87, DOI 10.3389/fgene.2013.00087

[8] Whole genome/exome sequencing in mood and psychotic disorders [J].

Kato, Tadafumi .

PSYCHIATRY AND CLINICAL NEUROSCIENCES, 2015, 69 (02) :65-76

[9]

Kliegman R, 2011, NELSON TXB PEDIAT, P357

[10] Identification of novel loci for bipolar I disorder in a multi-stage genome-wide association study [J].

Kuo, P. H. ;

Chuang, L. C. ;

Liu, J. R. ;

Liu, C. M. ;

Huang, M. C. ;

Lin, S. K. ;

Sun, H. Sunny ;

Hsieh, M. H. ;

Hung, H. ;

Lu, R. B. .

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2014, 51 :58-64

← 1 2 3 →