N6-Adenosine Methylation (m6A) RNA Modification: an Emerging Role in Cardiovascular Diseases

被引：42

作者：

Chen, Ye-shi ^{[1
]}

Ouyang, Xin-ping ^{[2
,3
]}

Yu, Xiao-hua ^{[4
]}

Novak, Petr ^{[5
]}

Zhou, Le ^{[5
]}

He, Ping-ping ^{[1
,3
]}

Yin, Kai ^{[5
]}

机构：

[1] Univ South China, Sch Nursing, Hengyang 421001, Hunan, Peoples R China

[2] Univ South China, Hengyang Med Coll, Hengyang Key Lab Neurodegenerat & Cognit Impairme, Dept Physiol,Neurosci Inst, Hengyang 421001, Hunan, Peoples R China

[3] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Hunan, Peoples R China

[4] Hainan Med Univ, Inst Clin Med, Affiliated Hosp 2, Haikou 460106, Hainan, Peoples R China

[5] Guilin Med Univ, Affiliated Hosp 2, Guangxi Key Lab Diabet Syst Med, Guilin 541100, Peoples R China

来源：

JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH | 2021年 / 14卷 / 05期

关键词：

Epitranscriptomics; N6-methyladenosine (m(6)A); Methyltransferase; Demethylase; Cardiovascular diseases; MESSENGER-RNA; INSULIN-RESISTANCE; NUCLEAR-RNA; DNA METHYLATION; DEMETHYLASE ALKBH5; GENE-EXPRESSION; HEART-FAILURE; FOOD-INTAKE; FTO; OBESITY;

D O I：

10.1007/s12265-021-10108-w

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

N6-methyladenosine (m(6)A) is the most abundant and prevalent epigenetic modification of mRNA in mammals. This dynamic modification is regulated by m(6)A methyltransferases and demethylases, which control the fate of target mRNAs through influencing splicing, translation and decay. Recent studies suggest that m(6)A modification plays an important role in the progress of cardiac remodeling and cardiomyocyte contractile function. However, the exact roles of m(6)A in cardiovascular diseases (CVDs) have not been fully explained. In this review, we summarize the current roles of the m(6)A methylation in the progress of CVDs, such as cardiac remodeling, heart failure, atherosclerosis (AS), and congenital heart disease. Furthermore, we seek to explore the potential risk mechanisms of m(6)A in CVDs, including obesity, inflammation, adipogenesis, insulin resistance (IR), hypertension, and type 2 diabetes mellitus (T2DM), which may provide novel therapeutic targets for the treatment of CVDs.

引用

页码：857 / 872

页数：16

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