The in silico insights of α-adrenergic receptors over the last decade:: Methodological approaches and structural features of the 3D models

被引：6

作者：

Carrieri, Antonio ^{[1
]}

Fano, Alessandra ^{[1
]}

机构：

[1] Dipartimento Farmaco Chima, I-70125 Bari, Italy

来源：

CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2007年 / 7卷 / 02期

关键词：

GPCR; homology modeling; docking; mutagenesis;

D O I：

10.2174/156802607779318181

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Homology modeling has been widely used in the latest years in order to overcome the lackness of adequate structural information. This technique has also been successfully applied in the very difficult but challenging field of G-protein coupled receptors where the need of three-dimensional insight is significantly more essential. Here we will review the latest advancements in this topic taking as case studies alpha-adrenergic receptors theoretical models and their structural features.

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页码：195 / 205

页数：11

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