Myeloid-derived suppressor cells in the era of increasing myeloid cell diversity

被引：1212

作者：

Veglia, Filippo ^{[1
]}

Sanseviero, Emilio ^{[2
]}

Gabrilovich, Dmitry I. ^{[3
]}

机构：

[1] H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL USA

[2] Wistar Inst Anat & Biol, 3601 Spruce St, Philadelphia, PA 19104 USA

[3] AstraZeneca, Gaithersburg, MD 20878 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2021年 / 21卷 / 08期

关键词：

TRANS-RETINOIC ACID; UNFOLDED PROTEIN RESPONSE; REDUCED CLINICAL BENEFIT; CIRCULATING TUMOR-CELLS; IMMUNE SUPPRESSION; GEMTUZUMAB OZOGAMICIN; PREMETASTATIC NICHE; ARGINASE-I; TH17; CELLS; T-CELLS;

D O I：

10.1038/s41577-020-00490-y

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Myeloid-derived suppressor cells (MDSCs) are pathologically activated neutrophils and monocytes with potent immunosuppressive activity. They are implicated in the regulation of immune responses in many pathological conditions and are closely associated with poor clinical outcomes in cancer. Recent studies have indicated key distinctions between MDSCs and classical neutrophils and monocytes, and, in this Review, we discuss new data on the major genomic and metabolic characteristics of MDSCs. We explain how these characteristics shape MDSC function and could facilitate therapeutic targeting of these cells, particularly in cancer and in autoimmune diseases. Additionally, we briefly discuss emerging data on MDSC involvement in pregnancy, neonatal biology and COVID-19.

引用

页码：485 / 498

页数：14

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