American College of Critical Care Medicine Clinical Practice Parameters for Hemodynamic Support of Pediatric and Neonatal Septic Shock

被引：482

作者：

Davis, Alan L.

Carcillo, Joseph A. ^{[1
]}

Aneja, Rajesh K. ^{[1
]}

Deymann, Andreas J. ^{[2
]}

Lin, John C. ^{[3
]}

Nguyen, Trung C. ^{[4
]}

Okhuysen-Cawley, Regina S. ^{[4
]}

Relvas, Monica S. ^{[5
]}

Rozenfeld, Ranna A. ^{[6
]}

Skippen, Peter W. ^{[7
]}

Stojadinovic, Bonnie T. ^{[8
]}

Williams, Eric A. ^{[9
]}

Yeh, Tim S. ^{[10
]}

Balamuth, Fran ^{[11
,12
]}

Brierley, Joe ^{[13
]}

de Caen, Allan R. ^{[14
]}

Cheifetz, Ira M. ^{[15
]}

Choong, Karen ^{[16
,17
,18
]}

Conway, Edward, Jr. ^{[19
]}

Cornell, Timothy ^{[20
]}

Doctor, Allan ^{[21
,22
]}

Dugas, Marc-Andre ^{[23
]}

Feldman, Jonathan D. ^{[24
]}

Fitzgerald, Julie C. ^{[25
]}

Flori, Heidi R. ^{[26
]}

Fortenberry, James D. ^{[27
]}

Graciano, Ana Lia ^{[28
]}

Greenwald, Bruce M. ^{[29
]}

Hall, Mark W. ^{[30
]}

Han, Yong Yun ^{[31
]}

Hernan, Lynn J. ^{[32
]}

Irazurta, Jose E. ^{[33
]}

Iselin, Elizabeth ^{[34
]}

van der Jagt, Elise W. ^{[35
]}

Jeffries, Howard E. ^{[36
]}

Kache, Saraswati ^{[37
]}

Katyal, Chhavi ^{[38
]}

Kissoon, Niranjan Tex ^{[39
,40
]}

Kon, Alexander A. ^{[41
,42
]}

Kutko, Martha C. ^{[43
]}

MacLaren, Graeme ^{[44
,45
,46
]}

Maul, Timothy ^{[47
]}

Mehta, Renuka ^{[48
]}

Odetola, Fola ^{[49
]}

Parbuoni, Kristine ^{[50
]}

Paul, Raina ^{[51
]}

Peters, Mark J. ^{[52
,53
]}

Ranjit, Suchitra ^{[54
,55
]}

Reuter-Rice, Karin E. ^{[56
,57
]}

Schnitzler, Eduardo J. ^{[58
]}

机构：

[1] Univ Pittsburgh, Sch Med, Dept Crit Care Med & Pediat, Pittsburgh, PA 15260 USA

[2] Indiana Univ, Riley Hosp Children, Dept Pediat Crit Care, Bloomington, IN 47405 USA

[3] Washington Univ, Sch Med, Dept Pediat, St Louis, MO 63110 USA

[4] Texas Childrens Hosp, Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA

[5] Texas Tech Univ, Covenant Women & Childrens Hosp, Pediat Crit Care Med, Lubbock, TX 79409 USA

[6] Northwestern Univ, Dept Pediat, Feinberg Sch Med, Div Pediat Crit Care Med, Chicago, IL 60611 USA

[7] Univ British Columbia, Div Pediat Crit Care, Vancouver, BC, Canada

[8] Med Coll Wisconsin, Dept Pediat, Div Pediat Crit Care Med, 8701 Watertown Plank Rd, Milwaukee, WI 53226 USA

[9] Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA

[10] St Barnabas Hosp, Dept Pediat, Livingston, NJ USA

[11] Univ Penn, Childrens Hosp Philadelphia, Perelman Sch Med, Div Emergency Med, Philadelphia, PA 19104 USA

[12] Univ Penn, Childrens Hosp Philadelphia, Perelman Sch Med, Ctr Pediat Clin Effectiveness, Philadelphia, PA 19104 USA

[13] Great Ormond St Hosp Sick Children, Intens Care & Bioeth, London, England

[14] Univ Alberta, Stollery Childrens Hosp, Dept Pediat, Pediat Crit Care Med, Edmonton, AB, Canada

[15] Duke Childrens, Dept Pediat, Div Pediat Crit Care Med, Durham, NC USA

[16] McMaster Univ, McMaster Childrens Hosp, Pediat Intens Care Unit, Dept Pediat, Hamilton, ON, Canada

[17] McMaster Univ, McMaster Childrens Hosp, Pediat Intens Care Unit, Dept Crit Care, Hamilton, ON, Canada

[18] McMaster Univ, McMaster Childrens Hosp, Pediat Intens Care Unit, Dept Clin Epidemiol & Biostat, Hamilton, ON, Canada

[19] Beth Israel Deaconess Med Ctr, Hartsdale, NY USA

[20] Univ Michigan, Dept Pediat & Communicable Dis, Ann Arbor, MI 48109 USA

[21] Washington Univ, Sch Med, Dept Pediat, St Louis, MO 63110 USA

[22] Washington Univ, Sch Med, Dept Biochem, St Louis, MO 63110 USA

[23] Univ Laval, CHU Quebec, Ctr Mere Enfant Soleil, Dept Pediat, Quebec City, PQ, Canada

[24] Kaiser Santa Clara Med Ctr, Dept Inpatient Pediat, Santa Clara, CA USA

[25] Univ Penn, Childrens Hosp Philadelphia, Perelman Sch Med, Dept Anesthesiol & Crit Care Med, Philadelphia, PA 19104 USA

[26] Univ Mott CS Childrens Hosp, Dept Pediat, Div Pediat Crit Care Med, Ann Arbor, MI USA

[27] Emory Univ, Sch Med, Dept Pediat, Div Crit Care, Atlanta, GA USA

[28] Univ Maryland, Sch Med, Dept Pediat Crit Care Med, Baltimore, MD 21201 USA

[29] Weill Cornell Med Coll, Div Pediat Crit Care Med, New York, NY USA

[30] Nationwide Childrens Hosp, Dept Pediat, Div Crit Care Med, Columbus, OH USA

[31] Childrens Mercy Hosp, Dept Crit Care Med, Kansas City, MO 64108 USA

[32] Texas Tech Univ, Hlth Sci Ctr, Dept Pediat, El Paso, TX USA

[33] Univ Florida, Div Pediat Crit Care, Jacksonville, FL USA

[34] Bon Secours St Marys Hosp, Glen Allen, VA USA

[35] Univ Rochester, Sch Med & Dent, Dept Pediat, Div Pediat Crit Care, Rochester, NY 14642 USA

[36] Univ Washington, Sch Med, Dept Pediat, Seattle, WA 98195 USA

[37] Stanford Univ, Sch Med, Dept Pediat, Div Crit Care, Palo Alto, CA 94304 USA

[38] Childrens Hosp Montefiore, Albert Einstein Coll Med, Pediat Hosp, Pediat Crit Care Med, Bronx, NY USA

[39] Univ British Columbia, Dept Pediat, Vancouver, BC, Canada

[40] BC Childrens Hosp, Crit Care Global Child Hlth, Vancouver, BC, Canada

[41] Naval Med Ctr San Diego, Dept Pediat, San Diego, CA USA

[42] Univ Calif San Diego, Sch Med, San Diego, CA 92103 USA

[43] Valley Hosp, Dept Pediat & Pediat Crit Care Med, Ridgewood, NJ USA

[44] Natl Univ Singapore Hosp, Cardiothorac ICU, Singapore, Singapore

[45] Royal Childrens Hosp, Paediat ICU, Melbourne, Vic, Australia

[46] Univ Melbourne, Dept Paediat, Melbourne, Vic, Australia

[47] Childrens Hosp Pittsburgh, Pittsburgh, PA 15213 USA

[48] Augusta Univ, Med Coll Georgia, Dept Pediat, Augusta, GA USA

[49] Univ Michigan, Dept Pediat, Div Crit Care Med, Ann Arbor, MI 48109 USA

[50] Loma Linda Univ, Dept Pharm Practice, Loma Linda, CA 92350 USA

来源：

CRITICAL CARE MEDICINE | 2017年 / 45卷 / 06期

关键词：

hemodynamics; newborn; pediatric; septic shock; EXTRACORPOREAL MEMBRANE-OXYGENATION; PERSISTENT PULMONARY-HYPERTENSION; BIRTH-WEIGHT INFANTS; RANDOMIZED CONTROLLED-TRIAL; RENAL-REPLACEMENT THERAPY; MULTIPLE ORGAN FAILURE; VENA-CAVA FLOW; INTRAVENOUS ARGININE-VASOPRESSIN; FEMORAL-ARTERY THERMODILUTION; CENTRAL VENOUS CANNULATION;

D O I：

10.1097/CCM.0000000000002425

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Objectives: The American College of Critical Care Medicine provided 2002 and 2007 guidelines for hemodynamic support of newborn and pediatric septic shock. Provide the 2014 update of the 2007 American College of Critical Care Medicine "Clinical Guidelines for Hemodynamic Support of Neonates and Children with Septic Shock': Design: Society of Critical Care Medicine members were identified from general solicitation at Society of Critical Care Medicine Educational and Scientific Symposia (2006-2014). The PubMed/Medline/Embase literature (2006-14) was searched by the Society of Critical Care Medicine librarian using the keywords: sepsis, septicemia, septic shock, endotoxemia, persistent pulmonary hypertension, nitric oxide, extracorporeal membrane oxygenation, and American College of Critical Care Medicine guidelines in the newborn and pediatric age groups. Measurements and Main Results: The 2002 and 2007 guidelines were widely disseminated, translated into Spanish and Portuguese, and incorporated into Society of Critical Care Medicine and American Heart Association/Pediatric Advanced Life Support sanctioned recommendations. The review of new literature highlights two tertiary pediatric centers that implemented quality improvement initiatives to improve early septic shock recognition and first-hour compliance to these guidelines. Improved compliance reduced hospital mortality from 4% to 2%. Analysis of Global Sepsis Initiative data in resource rich developed and developing nations further showed improved hospital mortality with compliance to first-hour and stabilization guideline recommendations. Conclusions: The major new recommendation in the 2014 update is consideration of institution specific use of 1) a "recognition bundle" containing a trigger tool for rapid identification of patients with septic shock, 2) a "resuscitation and stabilization bundle" to help adherence to best practice principles, and 3) a "performance bundle" to identify and overcome perceived barriers to the pursuit of best practice principles.

引用

页码：1061 / 1093

页数：33

共 391 条

[1] Intravenous Arginine Vasopressin Infusion in Refractory Vasodilatory Shock: A Clinical Study [J].