A history of the DNA repair and mutagenesis field The discovery of base excision repair

被引：28
|
作者：
Friedberg, Errol C. [1 ]
机构：
[1] Univ Texas SW Med Ctr Dallas, Dept Pathol, Dallas, TX 75390 USA
来源：
DNA REPAIR | 2016年 / 37卷
关键词：
ESCHERICHIA-COLI; ENDONUCLEASE; 2; N-GLYCOSIDASE; SUBSTRATE-SPECIFICITY; DEOXYRIBONUCLEIC-ACID; DEPURINATED DNA; PURINE-BASES; DEGRADATION; URACIL; PURIFICATION;
D O I：
10.1016/j.dnarep.2015.12.003
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
This article reviews the early history of the discovery of an DNA repair pathway designated as base excision repair (BER), since in contrast to the enzyme-catalyzed removal of damaged bases from DNA as nucleotides [called nucleotide excision repair (NER)], BER involves the removal of damaged or inappropriate bases, such as the presence of uracil instead of thymine, from DNA as free bases. (C) 2015 Published by Elsevier B.V.
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页码：A35 / A39
页数：5
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