Association of obesity and atrial fibrillation among middle-aged and elderly Chinese

被引:52
作者
Zhang, X. [2 ]
Zhang, S. [3 ,4 ,5 ]
Li, Y. [4 ,5 ,6 ]
Detrano, R. C. [7 ]
Chen, K. [3 ,4 ,5 ]
Li, X. [4 ,5 ,6 ]
Zhao, L. [4 ,5 ,6 ]
Benjamin, E. J. [8 ,9 ]
Wu, Y. [1 ,10 ]
机构
[1] Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China
[2] Beijing Municipal Hlth Bur, Sci & Educ Div, Beijing, Peoples R China
[3] Chinese Acad Med Sci, Cardiovasc Inst, Ctr Arrhythmia Diag & Treatment, Beijing 100037, Peoples R China
[4] Chinese Acad Med Sci, Fuwai Hosp, Beijing 100037, Peoples R China
[5] Peking Union Med Coll, Beijing 100021, Peoples R China
[6] Chinese Acad Med Sci, Cardiovasc Inst, Div CVD Prevent & Control Network, Beijing 100037, Peoples R China
[7] Univ Calif Irvine, Irvine, CA USA
[8] Sch Med, Dept Med, Cardiol Sect, Boston, MA USA
[9] Boston Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA USA
[10] George Inst, Beijing, Peoples R China
关键词
atrial fibrillation; epidemiology; body mass index; waist circumference; BODY-MASS INDEX; OBSTRUCTIVE SLEEP-APNEA; RISK-FACTORS; WAIST CIRCUMFERENCE; INDEPENDENT RISK; HEART-FAILURE; DISEASE RISK; FOLLOW-UP; ONSET; PREVALENCE;
D O I
10.1038/ijo.2009.157
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: To examine the associations between body mass index (BMI), waist circumference (WC) and risk of atrial fibrillation (AF) in Chinese adults. Design, Subjects and Measurements: A cross-sectional study was conducted to explore the association between obesity and atrial fibrillation among 18 615 Chinese (10 370 females) aged 35 years and above in 2004. AF was defined by electrocardiography and history. Obesity was classified by BMI and WC, including overweight (BMI: 24.0-27.9 kg m(-2); WC: 85.0-94.9 cm for men and 80.0-89.9 cm for women) and obesity (BMI: >= 28.0kg m(-2); WC: >= 95 cm for men and >= 90 cm for women), according to the Chinese Guidelines on Prevention and Treatment of Obesity in Adults. Multivariable logistic regression was used to analyze the association between obesity and AF. Results: Age- and sex-adjusted prevalence of AF (n = 194) was higher with increased BMI, with 0.9% for normal, 1.1% for overweight and 1.6% for obese (P-trend < 0.01) Chinese. Compared with normal BMI, multivariable-adjusted odds ratios (ORs) were 1.2 (95% confidence interval (CI): 0.8-1.7) for overweight BMI and 1.8 (95% CI: 1.2-2.8) for obese BMI (P-trend < 0.01). After excluding known secondary AF (valvular, postoperative and hyperthyroid) and unclassified AF, the corresponding multivariable-adjusted ORs were 1.4 (95% CI: 0.9-2.2) and 2.2 (95% CI: 1.3-3.7) (P-trend < 0.01). The same trends were observed for WC. Multivariable-adjusted OR was 2.6 (95% CI: 1.4-4.6) for participants with both BMI and WC obesity and 1.7 (95% CI: 1.0-2.9) for participants with both BMI and WC overweight in comparison with those with both BMI and WC in the normal range. Conclusion: Obesity, either defined by BMI or WC, was significantly associated with AF among middle-aged and elderly Chinese. International Journal of Obesity (2009) 33, 1318-1325; doi:10.1038/ijo.2009.157; published online 11 August 2009
引用
收藏
页码:1318 / 1325
页数:8
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